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36 Cards in this Set
- Front
- Back
define repair |
restoring the normal function and structure of a tissue |
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define wound |
short term, acute injury at a specific site |
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what is regeneration
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complete or near complete recovery of functional cells (parenchyma) and the supporting cell network (stroma); no scar |
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what is healing
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partial or incomplete recovery of the tissue, fibrous scar is made |
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shortlife span and are replaced from a reserve of continuously reproducing stem cells. |
labile cells |
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have a life span of months to years. Theyreproduce slowly unless there is injury. |
stable cells |
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are not capable of regeneration. They must lasta lifetime. |
permanent cells |
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these cells are in organs that are metabolicallyactive |
stable cells |
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Cells of this type are in the skin, the bonemarrow, the intestinal epithelium cells, bronchial epithelium cells, thelymphoid organs, urinary and genital tract cells |
labile cells |
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Cells of this type are cardiac, cells of thelens and skeletal muscle cells and neurons |
permanent cells |
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what is the basement membrane? |
a thin, filmy membrane that underlies all endothelium |
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what is the extracellular matrix? |
collage, elastin and fibroblasts; to make a mesh of supporting network |
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function of integrins |
from cell to cell connections in the extracellular matrix |
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epidermal growth factors come from? |
macrophages and platelets |
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function of epidermal growth factors |
fibroblasts and endothelial cells to migrate and reproduce |
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vascular endothelial growth factors are derived from what? |
fibrocytes and muscle cells |
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function of vascular endothelial growth factors? |
increase permeability and endothelial cell division |
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how long after an injury does angioneogenesis start? |
48-72 hours after injury |
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after collagen is deposited to the injury site, what 3 things happen to it? |
contraction, reshaping and strengthening |
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describe cell migration to the wound in 4 steps |
leukocytes clear the wound, then they make cytokines that attract myofibroblasts, angioblasts form new capillaries at the site of injury, myofibroblasts fill the rest of the injury w collagen that pulls the tissue back together forming the supporting network |
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what is the composition of granulation tissue? |
fibroblasts, edema and leukocytes |
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what type of wounds does healing by first intention occur in? |
narrow wounds |
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describe healing by first intention in 5 steps |
neutrophils come and clear the site, then replaced by macrophages, then angioneogenesis then collagen laid down by fibroblasts, then a pink scar is formed and blood vessels leave the area |
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tensile strength of the wound is what % of the original tissue? |
10% |
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at 3 months after first intention healing began, what is the tensile strength? |
75% |
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at 1 year after first intentions healing began what is the tensile strength? |
almost 100% |
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what type of wound is second intention healing seen in? |
wide and deep wounds |
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describe process of second intention healing |
granulation tissue clumps and fills the large found, a lot of necrotic tissue, then endothelial cells lay a thin membrane over the granulation tissue and granulation evolves into a scar |
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what is the most common cause of abnormal wound healing? |
infection |
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poor nutrition of what can interfere with wound healing? |
decrease amounts of vitamin c and protein |
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define the term dehisence
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wounds that do not heal properly and burst or rupture |
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wounds located where in the body is a common example of dehisence? |
abdominal wound |
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Cells of this type are cardiac, cells of thelens and skeletal muscle cells and neurons. |
keloid |
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keloids are common in what population? |
african descent |
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localized, highly vascular, persistentgranulation tissue. The tissue has lost its inflammatory infiltrate and oedemafluid. They look like a benign vascular tumour |
pyogenic granuloma |
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regrowth of nervous connections (periphery) occur at what rate? |
1 mm/day |