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10 Cards in this Set
- Front
- Back
Anemia classification
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Morfologic criteria:
-According to MCV: (80 – 95 fl) -micro-, normo-, macrocytic -According to MCH: (27-32 pg) normochrome, hypochrome -According to no of reticulocytes: (0,7 – 2,8 %) anaemia with lowered, normal or incresed no of reticulocytes |
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MICROCYTIC ANAEMIA
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Iron deficiency anaemia
Chronic disease anaemia Thalasemia Sideroblastic anaemia |
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MACROCYTIC ANAEMIA
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Megaloblastic anaemia:
lack of B12, folic acid, myelodysplastic syndrome (MDS) Macrocytic non-megaloblaste anaemia (usually secondary) |
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NORMOCYTIC ANAEMIA
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Primar impairment of blood marrow:
aplastic anaemia, MDS, paroxysmal nocturnal hemoglobinuria (PNH), myelofibrosis. Secondary impairment of blood marrow : infiltration, infection, endocrinological and systemic diseases, ACD |
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ANAEMIA WITH RETICULOSIS
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- Haemolytic aneamia corpuscular
- Haemolytic anaemia extracorpuscular (imunne and non-immune based) |
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Alpha-thalassemia
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1) - α/ α α = silent carrier
2) - α/- α , - - / α α = carrier (mikrocytosis, erythrocytosis): = Thalassemia minor 3) - - / - α = HbH (β4) (splenomegalia, mikrocytosis, bones) 4) - - / - - = hydrops fetalis, sy Hb Bart´s (γ4) |
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Where do we find Heinz bodies?
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Target cells in HbH disease
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Beta-thalassemia minor
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(β+/ β, β0/ β)
Mikrocytosis, anaemia, erythrocytosis |
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Beta-thalassemia intermedia
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(β+/ β+, β0/ β+)
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Beta-thalassemia major
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(β0/ β0, β+/ β+)
Severe anemia, anisopoikilocytosis, affected ERY, HbF, hepatosplenomegalia, bone deformities, permanent transfusion therapy, Fe overload, Tx, splenectomia, (HU (??)) |