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21 Cards in this Set
- Front
- Back
alpha blockers (a1,a2)
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PHENOXYBENZAMINE (a1 greater/ equal a2)
ALKALOIDS (from plants) (a1>>) |
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indirect-acting antiadernertic
(ihibit cate syn) |
METYROSINE
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a/b blocekrs
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labetalol b1=b2>a1
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b blockers
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propranolol
pindolol timolol sotalol |
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b1
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metoprolol, acebutrolol, bisoprolol (good for stable heart failure)
atenolol esmolol |
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a1
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prazosin
tamsulosin |
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two mechanisms
irreversible reversible |
irrs- PHENOXYBENZAMINE , covalent
revers - everything else |
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a1 antag
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prazosin/tamsulosin
HELPS WITH PROSTATE arterial/venous vasodilation EPI effect is REVERESED ADRENERGIC SWEATING STOPPED FALL IN BP! oral bio 60-90% distrubites all tissues (brain too) |
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a1 - antag effects
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Baroreceptors blocked when u stand up
Cardio - first dose hypotension (syncope), myocardial/cerebral ischemia perif EDeMA, w/ chronic treatment uninary freq/inconticance up sexual disfunction, inhibit ejact |
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a1-antag uses
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Pheochomocytoma (then u gotta use b blockers)
use in prostatic hypertrophy (rlx bladder) raynaur'ds disease (cold finger tips) chronic hypertension/emergency |
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nonselctive a antag
(phenoxybenzamine) |
vaso dilation (perifer)
increase of HR (enchance NE release, reflex) EPi reversed HD - inhibtit cat reuptake (phenoxybenazmine) could last up to 7 days oral bio 30%, all tissues 24 hrs 1/2 life |
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b antag
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local anestheic (Na+) channels
affects are PRONOUNCED when symp tone is high/SMALL when tone is low ALL VASODILATION BLOCKED |
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b antag
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CVS - lower cardiac output
vessels - TPR inrease intially (reflex), normalizaed later resp - broncoconst nml...bad with ppl with ASTHMA) ocular - decreased rate of aq humor metabolism - decreased renin |
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timolol
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lower intra occ press
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sotalol
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pronounced K+ blocking actvity
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a-b antag
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labetol/carevediol
labetol - anesthetic activy cav - none decreased of TPR |
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b antag
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lipid SOLUBILTY!
prop,meto, labetoal low bioavail/big first pass/cross BBB |
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b-antag adverse affects
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CVS - perip vasc spams
heart failure, withrdrwal affects resp...= increase resistance sexual dysfunction (with chroinc treatments) |
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contraindiactions
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vascospaic angina - block b2, cause a1 vasoconstction
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USES of b blockers
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hypertension
arrhythimias exertional angina open/closed in glaucoma |
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indirect acting
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Metyrosinse - inhibit tyrosine hydroxylase (up to 70%)
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