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43 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Antimetabolites
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Inhibit synthesis of DHF, ultimately nucleic acid synthesis
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Antimetabolites, Sulfonamides, Trimethoprim
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Sulfonamides
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Inhibit synthesis of DHF, ultimately nucleic acid synthesis
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Antimetabolites, Sulfonamides, Trimethoprim
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Trimethoprim
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Inhibit synthesis of DHF, ultimately nucleic acid synthesis
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Antimetabolites, Sulfonamides, Trimethoprim
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Flucytosine
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Inhibits thymidylate synthetase, ultimately DNA synthesis
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Flucytosine (antimetabolite)
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Isoniazid
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Inhibits production of mycolic acid (specific to mycobacteria)
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Isoniazid, Rifampin, Ethambutol, Pyrazinamide
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Penicillin
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Interfere with cell wall biosynthesis, inhibition of transpeptidation weakens cell wall, autolytic enzymes of bacteria then promote lysis.
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Penicillins, Cephalosporins (ß Lactams)
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Cephalosporins
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Interfere with cell wall biosynthesis, inhibition of transpeptidation weakens cell wall, autolytic enzymes of bacteria then promote lysis.
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Penicillins, Cephalosporins (ß Lactams)
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Cycloserine
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Interfere with cell wall biosynthesis
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Bacitracin
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Interfere with cell wall biosynthesis
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Glycopeptides
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Interfere with cell wall biosynthesis
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Vancomycin
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Interferes with cell wall biosynthesis
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Teichoplanin
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Interfere with cell wall biosynthesis
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Caspofungin
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Cycloserine, Bacitracin, Glycopeptides, Vancomycin, Teichoplanin, Caspofungin
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Polymyxins
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Disrupt membrane integrity
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Polymyxins, daptomycin, nystatin, amphotericin B, (last 2 are polyenes)
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Daptomycin
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Disrupt membrane integrity
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Polymyxins, daptomycin, nystatin, amphotericin B, (last 2 are polyenes)
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Nystatin
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Disrupt membrane integrity
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Polymyxins, daptomycin, nystatin, amphotericin B, (last 2 are polyenes)
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Amphotericin B
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Disrupt membrane integrity
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Polymyxins, daptomycin, nystatin, amphotericin B, (last 2 are polyenes)
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Streptomycin
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Inhibit protein synthesis by binding a specific 30S subunit protein
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Streptomycin (Aminoglycoside)
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Gentamicin
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Inhibit protein synthesis by binding multiple 30S subunit proteins
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Gentamicin, kanamycin, neomycin, amikacin, tobramycin (aminoglycosides)
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Kanamycin
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Inhibit protein synthesis by binding multiple 30S subunit proteins
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Gentamicin, kanamycin, neomycin, amikacin, tobramycin (aminoglycosides)
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Neomycin
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Inhibit protein synthesis by binding multiple 30S subunit proteins
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Gentamicin, kanamycin, neomycin, amikacin, tobramycin (aminoglycosides)
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Amikacin
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Inhibit protein synthesis by binding multiple 30S subunit proteins
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Gentamicin, kanamycin, neomycin, amikacin, tobramycin (aminoglycosides)
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Tobramycin
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Inhibit protein synthesis by binding multiple 30S subunits
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Gentamicin, kanamycin, neomycin, amikacin, tobramycin (aminoglycosides)
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Tetracyclines
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Block protein synthesis by inhibiting binding of charged tRNA to 30S
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Tetracycline, Doxycycline, Tigecycline
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Doxycycline
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Block protein synthesis by inhibiting binding of charged tRNA to 30S
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Tetracycline, Doxycycline, Tigecycline
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Tigecycline
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Block protein synthesis by inhibiting binding of charged tRNA to 30S
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Tetracycline, Doxycycline, Tigecycline
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Erythromycin
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Inhibit protein synthesis by binding 50S subunit, blocking elongation step
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Erythromycin, Azithromycin, Clindamycin, Chloramphenicol
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Azithromycin
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Inhibit protein synthesis by binding 50S subunit, blocking elongation step
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Erythromycin, Azithromycin, Clindamycin, Chloramphenicol
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Clindamycin
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Inhibit protein synthesis by binding 50S subunit, blocking elongation step
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Erythromycin, Azithromycin, Clindamycin, Chloramphenicol
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Chloramphenicol
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Inhibit protein synthesis by binding 50S subunit, blocking elongation step
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Erythromycin, Azithromycin, Clindamycin, Chloramphenicol
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Oxazolidinones
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Bind rRNA on both subunits
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Oxalidinones, Linezolid
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Linezolid
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Bind rRNA on both subunits
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Oxalidinones, Linezolid
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Dalfopristin
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Bind to 50S subunit
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Dalfopristin, Quinupristin (streptogramins)
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Quinupristin
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Bind to 50S subunit
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Dalfopristin, Quinupristin (streptogramins)
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Mupirocin
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Binds isoleucyl tRNA synthetase, prevents charging of Ile-tRNA, thus limiting protein synthesis
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Mupirocin
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Ciprofloxacin
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Inhibit bacterial DNA gyrase
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Ciprofloxacin, Moxifloxacin (Fluoroquinolones)
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Oxifloxacin
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Inhibit bacterial DNA gyrase
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Ciprofloxacin, Moxifloxacin (Fluoroquinolones)
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Metronidazole
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Fragment DNA
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Metronidazole (nitroimidazoles)
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Rifampin
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Binds bacterial RNA polymerase, blocks transcription
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Rifampin
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Fluconazole
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Inhibit ergosterol synthesis
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Fluconazole, Ketoconazole (Azoles)
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Ketoconazole
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Inhibit ergosterol synthesis
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Fluconazole, Ketoconazole (Azoles)
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Ethambutol
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Unknown, anti-M tuberculosis
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Ethambutol, Pyrazinamide
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Pyrazinamide
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Unknown, anti-M tuberculosis
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Ethambutol, Pyrazinamide
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