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14 Cards in this Set
- Front
- Back
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Isoprenaline
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Synthetic beta-selective agonist
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Phenyleephrine, Methoxamine (non-selective)
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Selective alpha1 agonist - causes constriction, used as nasal decongestant
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Dobutamine
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beta1 agonist - increase contractility, treat cardiogenic shock
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Salbutamol
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beta2 agonist - relax bronchial smooth muscle, treats asthma
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Indirectly acting sympathomimetics
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Similar structures to NA but do not activate receptors, enter via uptake 1 e.g. amphetamine (drug abuse), ephedrine (nasal decongestant)
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non-selective alpha antagonists?
effects, 4 drugs |
Causes hypotension, postural hypotension (alpha1 blockade)
Increases CO and causes tachycardia (alpha2 blockade) e.g. Phenoxybenzamine, Phenolamine Labetol and carvediol (alpha and beta actions reduces effect on heart) used to treat hypertension |
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Selective alpha1 antagonists? (3)
effets, use, side effects |
Caues vasodilation, fal in arterial presure
used as antihypertensive e.g. prazosin, doxaszosin, terazocin side effects - postural hypotension |
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Tamsulosin
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selective alpha1 antagonist, relaxes bladder smooth muscle, used to treat urinary retention associated with an enlarged protate
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Yohimbine
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selective alpha-2 antagonist, experimental, vasodilator and stimulant effects, used to treat male impotence, aphrodisiac, may incease fat burn
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Propranolol
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Beta1 and beta2 antagonist, contraindicated with salbutamol (beta2 agonist, treats asthma)
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Actions of beta antagonists? (4)
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1)reduces effect of exercise on cardiovascular system (lowers O2 demand of the heart)
2) antidysrhythmis effects in heart disease 3) antihypertensive - reduces CO, renin release and sympathetic activity (CNS activity) 4) prevent tremor |
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Side-effects of beta-antagonists?(6)
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1)bronchoconstriction (beta2)
2)Cardiac failure - reduce sympathetic tone 3)bradycardia 4)Hypoglycaemia (symptons that warn diabetics of it is reduced) 5) Fatigue (due to reduced CO) 6) cold extremities (loss of beta2 dilation) |
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Cardiovascular uses of beta antagonists? (3)
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1) hypertension
2)angina 3)cardiac disrhythmias (protective after MI) |
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Other uses of beta antagonists?(5)
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1)glaucoma (timolol)
2)anxiety 3)hyperthyroid disease 4)tremor 5)migrain |
