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28 Cards in this Set
- Front
- Back
mechanism of penicillin
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Binds PBPs and enzymes responsible forr peptidoglycan synthesis
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mechanism of cephalosporin
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Binds PBPs and enzymes responsible for peptidoglycan synthesis
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mechanism of cephamycin
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Binds PBPs and enzymes responsible for peptidoglycan synthesis
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mechanism of carbapenem
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Binds PBPs and enzymes responsible for peptidoglycan synthesis
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mechanism of monobactam
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binds PBPs and enzymes responsible for peptidoglycan synthesis
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mechanism and function of beta-lactamase inhibitors
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Binds beta-lactamases and prevents enzymatic inactivation of beta-lactam drugs such as penecillin (concurrent administration)
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mechanism of vancomycin
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inhibits cross-linkage of peptidoglycan layers by sterically interfering with D-alanine-D-alanine termini of peptidoglycan pentapeptide side chains
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mechanism of bacitracin
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inhibits bacterial cytoplasmic membrane and dephosphorylation of bactoprenol which moves peptidoglycan precursors out of cell
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mechanism of polymixin
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inhibits bacterial membranes by acting as a detergent and increasing permeability`
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mechanism of isoniazid
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synthesis of mycolic acid affected by disrupting elongation of fatty acids and hydroxy lipids; exact mechanism unknown
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mechanism of ethionamide
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disrupts cell walls by disrupting synthesis of mycolic acid.
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mechanism of cycloserine
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inhibits cross-linkage of peptidoglycan layers by inhibiting d-alanine-d-alanine synthetase and alanine racemase
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mechanism of aminoglycoside
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irreversibly binds 30S ribosomal subunit and causes abberant protein production and premature release of the ribosome
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mechanism of tetracycline
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reversibly binds 30S ribosomal subunits and prevents polypeptide elongation by blocking tRNA binding
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mechanism of oxazolidinone
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binds 50S ribosomal subunit and does not allow formation of 70S initiation complex thus preventing protein synthesis
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mechanism of macrolide
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reversibly bind 23S rRNA of the 50S ribosomal subunit which blocks polypeptide elongation.
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mechanism of clindamycin
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binds to the 50S ribosome and blocks protein elongation.
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mechanism of streptogramin
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binds to the 50S ribosome and blocks protein elongation.
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mechanism of chloramphenicol
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reversibly binds to the 50S ribosomal subunit thus blocking peptide elongation
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mechanism of quinolones
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binds DNA topoisomerases such as the alpha unit of DNA gyrase.
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mechanism of rifampin
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prevents transcription by binding DNA-dependent RNA polymerase
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mechanism of rifabutin
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prevents transcription by binding DNA-dependent RNA polymerase
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mechanism of metronidazole
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reduction of metronidazole's nitro group creates a cytotoxic compound that disrupts the host DNA.
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mechanism of metronidazole
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reduction of metronidazole's nitro group creates a cytotoxic compound that disrupts the host DNA.
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mechanism of sulfonamide
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competes with p-aminobenzoic acid to prevent synthesis of folic acid
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mechanism of dapsone
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inhibits dihydropteroate synthase, anti-folate
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mechanism of trimethoprim
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inhibits dihydrofolate reductates and distrupts folic acid synthesis
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mechanism of fosfomycin
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inhibits the first step in peptidoglycan synthesis where UDP-N-acetylglucosamine combines with PEP to form N-acetylmuramic acid
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