Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
|
The matured N-and O-linked sugar moieties of glycoproteins are
pre-determined by the complexity of their pre-assembled core oligosaccharides. |
False
|
|
|
All glycoproteins are first synthesized by free ribosomes.
|
True
|
|
|
A cell controls the quality of ER-made proteins by targeting the
mis-folded proteins to lysosome for degradation. |
False
|
|
|
Cleavage of signal peptide sequence is an essential step for protein
synthesis to resume in ER. |
False
|
|
|
The low pH of late endosome facilitates the dissociation of ligand receptor
complex during receptor mediated sorting process. |
True
|
|
|
The N-linked core oligosaccharide is built up on the phosphate group of
dolichol phosphate by the successive addition of monosaccharide (monomeric sugar) units. |
True
|
|
|
In receptor mediated endocytosis, invagination of the plasma
membrane precedes formation of a clathrin lattice around the cytosolic side of plasma membrane. |
False
|
|
|
Tunicamycin blocks addition of UDP-GlcNAc to dolichol phosphate
carrier. |
True
|
|
|
Proteins that contain internal sorting sequences retain the signals as a
part of their final protein conformation. |
True
|
|
|
Operon is a universal gene unit.
|
False
|
|
|
The function of N-terminal signal peptide in the preproinsulin is to
direct it to the ER, from which it enters the Golgi complex and is packaged into a secretory vesicle for transport into extracellular compartment. |
True
|
|
|
Mannose-6-phosphate is a key signal for directing proteins to lysosome
for degradation |
False
|
|
|
All RNA polymerases can bind promoter by itself.
|
False
|
|
|
Eukaryotic RNA polymerase II can not bind promoter by itself.
|
True
|
|
|
Prokaryotic RNA polymerase can not bind promoter by itself.
|
False
|
|
|
Transcription in trp operon is terminated when initiation of the
translation of the leader peptide (region 1) is blocked. |
False
|
|
|
CAP binds DNA.
|
False
|
|
|
An direct physical interaction between CAP-cAMP and i repressor
protein determines the final affinity of RNA polymerase binding to lac promoter. |
False
|
|
|
In ubiquitin-dependent 26S proteasome degradation pathway, the
substrate specificity of ubiquitination is determined by E2 enzyme. |
False
|
|
|
Translocon has three sorting signal sequences.
|
True
|
|
|
The lac operon is induced whenever lactose is present.
|
False
|
|
|
The elevated cAMP level that exists when glucose is high causes CAP to
bind the lac operon and initiate transcription. |
False
|
|
|
Attenuation in the trp operon of E. Coli is a mechanism for inhibiting
translation of existing (complete) trp mRNAs. |
False
|
|
|
IRE-BP acts as an inhibitor for ferritin protein synthesis when
intracellular iron level is low. |
True
|
|
|
KDEL sequence is found in flipase, translocon, and mannose-6-
phosphate receptor. |
False
|
|
|
The bacteria culture that contains DNA fragments from a eukaryotic
organism, which has been digested with a restriction enzyme and cloned into a lambda vector is known as cDNA library. |
False
|
|
|
The Southern technique involves the detection of DNA fragments on
membrane using a radioactive RNA probe. |
True
|
|
|
One of the most significant discoveries that allows the development of
recombinant DNA technology is the discovery of antibiotics used for selecting transformed bacteria. |
False
|
|
|
RFLP is a technique that is used to analyze alterations at a specific
genetic locus by restriction enzyme digestion, gel electrophoresis, and Southern blotting. |
True
|
