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16 Cards in this Set
- Front
- Back
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which is the most commonly used confirmatory method for identification of drugs of abuse?
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Gas chromatography
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A 4-year old previously healthy child ingests a 100 mL bottle containing a clear liquid he found under the kitchen sink at home. The child is observed to develop central nervous system depression over the next 6 hours. Acidosis is documented on admission to the hospital. Three weeks later, it is noted that the child's visual acuity is markedly decreased. Which of the following chemical substances was most likely present in the liquid ingested by this child?
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Methanol
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How is Carbon Monoxide measured?
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CO assays measure absorbance at specific wavelengths and %COHb is calculated
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Benzoylecgonine is the major metabolite of
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Cocaine
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Intoxification by acetaminophen results in
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Hepatocystic necrosis
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The primary product of ethanol metabolism by alcohol dehydrogenase is
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Acetaldehyde
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For a drug to enter the tissue and elicit the desired effect, it must be
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in the free state
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Clearance rate of a drug depends on
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its volume of distribution
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Calculate the therapeutic index for this drug:
Therapeutic range: 1 - 3 ug/mL Toxic range: ≥ 5 ug/mL |
5
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The period of time during which the concentration of a therapeutic drug decays by 50% is referred to as the
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half life of the drug
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The measured plasma concentration of gentamicin at noon is 10 ug/mL. At 4 pm, the gentamicin concentration was measured to be 6 ug/mL. The half life of this drug is approximately
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5 hours
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First pass effect refers to
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metabolism of a drug
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An example of a cardiac glycoside drug would be
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Digoxin
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Which of the following test results would indicate high risk for fetal lung immaturity
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L/S ratio of less than 2.0 and PG negative
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Transformation of the parent drug to its metabolites primarily occurs in the
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liver
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The active metabolite of procainamide is
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NAPA
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