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15 Cards in this Set
- Front
- Back
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Objectives
-To understand and be able to identify or define differences between apoptosis and other mechanisms resulting in cell death |
Objectives
-To understand and be able to identify or define differences between apoptosis and other mechanisms resulting in cell death |
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***What are caspases? (chemically) |
Cystein proteases that cleave after aspartic acid residue
(mnemonic= C, ASP) |
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What is the function of initiator caspases and what are their numbers? |
Involved in decision/commitment to apoptosis (only real way to prevent apoptosis)
Caspases 8, 9, 10 |
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What is the function of effector caspases and what are their numbers? |
Involved in execution of apoptosis
Caspases 3, 6, 7 |
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What caspase involved in promotion of inflammation and what is it activated via? |
Caspase 1 via IL-1 beta |
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Non-apoptotic function of Proliferation, Inflammation, and Differentiation of many cells through which caspases? |
Caspases 3 and 7
(these also effector caspases) |
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In order to be activated out zymogen form, caspases must undergo ___? |
Cleavage by other caspases or by itself |
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*What pathway is the mitochondrial pathway? |
Intrinsic Pathway |
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*What pathway is the death receptor-initiated pathway? |
Extrinsic Pathway |
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Caspases play additional role in __________ (hint caspase 1)
Also in 'response to ______" and ______? |
Role in Inflammation (Caspase 1)
Role in response to PRR (Pattern Recognition Receptors) as well as PAMPS |
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What 2 caspases play a role in proliferation and inflammation? |
Caspase 3 and 7 |
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Cytochrome C released in what pathway and what does it activate? |
Intrinsic
Activates initiator caspase (pro caspase 9) |
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In extrinsic pathway, receptor ligand interaction with either ______ or _________?
What do they both do? |
Fas or TNF-R
Fas removes immunce cells after adaptive immune response completes
TNF-R is important mediator of inflammation TNF-R induces apoptosis
TNF-R associates with TRADD, then TRADD binds FADD, leading to caspase activation |
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Which pathway?
Change in mitochondrial membrane --> Cytochrome C released and activates initiator complex (pro Caspase 9) --> Executioner caspase initiated |
Intrinsic Pathway |
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Which caspase is the initator caspase? |
ProCaspase 9 |
