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19 Cards in this Set
- Front
- Back
MOA of SSRIs |
Selectively inhibit the neuronal re-uptake of 5-HT, thus enhancing synaptic concentrations of 5-HT and downregulating presynaptic 5-HT receptors |
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Other than depression, what are some SSRIs licensed in? |
Anxiety disorders Panic disorders OCD |
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MOA of TCAs |
Inhibit the neuronal uptake of NA and 5-HT leading to augmented concentrations in the synaptic cleft. The increase in catecholamines may lead to down-regulation of presynaptic a-2 adrenoceptors and 5-HT receptors and postsynaptic b-adrenoceptors |
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Antimuscarinic SEs of TCAs |
Dry mouth Blurred vision Constipation Urinary retention Sedation Reduced motor co-ordination |
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Cardiac effects of TCAs |
QT interval prolongation Potentiation of catecholamines also predisposes to heart block and arrhythmias |
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MOA of NARIs |
Selectively inhibit NA reuptake |
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When are NARIs used? |
For patients who cannot take TCAs but are resistant to the effects of SSRIs |
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MOA of SNRIs? |
Inhibits serotonin and NA reuptake |
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What are SNRIs associated with causing? |
HTN |
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MOA of NaSSAs |
Alpha2-adrenoceptor antagonist activity, inhibiting negative feedback by these presynaptic receptors and thus producing an increase in NA and 5-HT transmission |
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SEs of NaSSAs |
Sedation in early treatment |
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MOA of SRMs |
Serotonin receptor modulators Inhibition of serotonin re-uptake and the selective inhibition of postsynaptic serotonin receptors |
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First line treatment for bipolar affective disorder? |
Lithium (for both acute treatment and prophylaxis) |
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When should lithium be avoided? |
In renal impairment |
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What is required during lithium treatment? |
Therapeutic drug monitoring |
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Which other drugs are used in bipolar affective disorder? |
Anticonvulsants: carbamazepine and valproate Neuroleptics (antipsychotics) |
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Basis of anxiety treatment? |
Benzodiazepines or beta blockers may offer symptomatic relief. Antidepressants may improve the long term outcome |
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What is buspirone? |
Activates 5-HT (1a) receptors, binds to dopamine receptors Delay of 2-3 weeks prior to an anxiolytic effect |
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SEs of buspirone? |
Dizziness Nausea Headache |