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15 Cards in this Set
- Front
- Back
What neural crest structures are found in each of the following adult structures? 1. Peripheral Nervous System 2. Ear 3. Eye 4. Mouth 5. Thyroid 6. Heart 7. Digestive System 8. Adrenal Glands 8. Skin |
1. Autonomic nervous system, dorsal root ganglia, sensory nerves, Schwann cells, CNs 2. Ossicle of the middle ear 3. Anterior chamber ( cornea, sclera, ciliary muscle, iris pigment cells) 4. Odontoblast 5. Parafollicular (C) cells 6. Aorticopulmonary septum (spiral septum) 7. Enteric nervous system 8. Chromaffin cells of the medulla 9. Melanocytes |
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Effects of these teratogenic drugs 1. ACE inhibitors 2. Aminoglycoside 3. Fluoroquinolone 4. Tetracycline 5. Cyclophosphamide 6. Methotrexate 7. Carbamazepine 8. Valproic acid 9. Phenytoin 10. Lithium 11. Statins 12. Warfarin 13. Isotretinoin 14. DES 15. Thalidomide |
1. Renal malformation 2. Ototoxicity 3. Cartilage damage 4. Discolored teeth 5. Ear/facial anomalies, limb hypoplasia, absence of digits 6. Neural tube defect, abortion 7. neural tube defect 8. Neural tube defect 9. Fetal hydantoin syndrome 10. Ebstein anomaly 11. CNS and limb abnormalities 12. Facial/ limbs/ CNS anomalies, spontaneous abortion 13. spontaneous abortion and birth defects 14. Clear cell vaginal adenocarcinoma 15. Phocomelia |
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Most common cause of neural tube defect |
Folate deficiency |
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Most common preventable cause of congenital malformation in the US |
Alcohol use in pregnancy |
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All cyclins are degraded by |
Ubiquitin protein ligase |
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Cyclin B - CDK 1 complex is activated by cdc25, that cause breakdown of |
Nuclear lamins and initiation of mitosis |
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Claude cornea, coarse facies, hepatosplenomegaly, skeletal abnormalities, restricted joint movement, lysosomal protein in peripheral blood |
I cell disease |
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Plasmalogens is synthesized by and found in? |
1. Peroxisome 2. Myelin |
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Stain use to identify these intermediate filaments 1. Cytokeratin 2. Desmin 3. GFPA 4. Neurofilament 5. Vimentin |
1. Carcinoma 2. Sarcoma - rhabdomyosarcoma- 3. Glioblastoma 4. Neuroblastoma 5. Sarcoma |
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Arachidonic acid pathway |
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What cellular by- products might you detect in the serum when the following cell types are injured 1. Cardiac myocytes 2. Skeletal myocytes 3. Hepatocytes 4. Salivary gland cells 5. Pancreatic exocrine cells 6. RBCs |
1. Myoglobin, CK, CKMB l, troponin I 2. CK, aldolase, myoglobin 3. AST, ALT, Alkaline phosphatase, GGT 4. Amylase 5. Amylase and lipase 6. Heme -> Bilirubin |
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Acute inflammatory mediators |
1. IL 1 2. IL 6 3. TNF alpha |
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Increase vasodilation and vascular permeability in acute inflammation |
1.Histamine 2. Serotonin 3. Bradykinin |
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Hyperflexible joint, arachnodactyly, aortic dissection, lens dislocation |
Marfan |
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Hereditary nephritis, cataracts, sensorineural hearing loss |
Alport syndrome |