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30 Cards in this Set
- Front
- Back
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What is the action of TRH?
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-Stimulates T3 & T4 from thyroid
-Simulates prolactin release |
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What stimulates release of TRH?
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-Cold
-Increased energy |
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What inhibits release of TRH?
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-Decreased energy availability
-Some physical stressors -Feedback from T3 & T4 |
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What is the action of CRH?
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-Stimulates ACTH release to activate adrenal cortex
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What stimulates release of CRN?
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-Stress
-Cytokines |
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What inhibits release of CRH?
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-Feedback from glucocorticoids
-Higher level of CNS input |
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What is the action of GHRH?
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-Stimulates GH secretion
-May influence sleep and feeding |
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What stimulates the release of GHRH?
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-Ghrelin
-Nutritional status (often dec'd nutrition, but leptin can stimulate) -Loss of somatostatin inhibition |
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What inhibits release of GHRH?
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-IGF-1 feedback
-Somatostatin |
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What is the action of somatostatin?
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-Inhibits GH secretion
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What stimulates release of somatostatin?
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-NPY
-CNS inputs (often stress associated) -GH and IGF-1 |
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What inhibits the release of somatostatin?
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-CNS inputs
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What is the action of dopamine?
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-Inhibits prolactin release
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What stimulates the release of dopamine?
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-Prolactin
-CNS inputs |
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What inhibits the release of dopamine?
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-Stimulation of nipple
-Estrogen |
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What are some things that can release prolactin?
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-TRH
-Vasopressin -Oxytocin -VIP |
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What is the action of GnRH?
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-Stimulates gonadotropin release
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What stimulates GnRH release?
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-CNS inputs
-Circadian rhythms |
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What inhibits the release of GnRH?
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-Estrogen & testosterone feedback
-CNS inputs |
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What are the actions of GH (often via somatomedins such as IGF-1)?
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-Promotes protein deposition
-Inc's bone and cartilage growth -Inc'd lypolysis -Dec'd CHO metabolism -"Anti-insulin" action |
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What are the actions of prolactin?
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-Stimulates milk production
-Development of mammary duct system -Facilitates immune response -Reduces gonadotropin levels |
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What are the actions of oxytocin?
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-Contraction of myoepithelial cells in mammary glands
-Contraction of uterine myometrium -Behavioral effects -Ejaculation in males |
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What is the action of vasopressin?
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-Water resorption in distal tubules and collecting ducts of kidney (V2 receptor/aquaporin)
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What are the actions of leptin?
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-Involved in body weight
-Reduces food intake -Increases metabolism -Facilitates reproduction -Bone growth |
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What is the action of resistin?
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-Decreases insulin sensitivity
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What are the actions of TNF-alpha, IL-6?
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-Decreases insulin sensitivity
-Promotes inflammatory response |
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What are the actions of adiponectin?
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-Increases insulin sensitivity
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What are the actions of IGF-1?
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-Facilitates growth
-Dec's insulin sensitivity (GH-like action) |
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What are the actions of estrogen/testosterone?
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-Phenotypic changes
-Reproductive problems |
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What is the function of incretins?
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-Facilitate insulin secretion
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