Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
RAS-d |
Ras cannot hydrolyze GTP, it's always associated with RAF, to make it you sterically block the gamma phosphate (G12-X amino acid change most often or Glu61-X) |
|
Kras |
Most common. G12 is mutational hotspot. |
|
Rigosertib, lonafarnib, and vemurafenib |
Rigosertib: Blocks Ras ability to bind to RAF. Lonafarnib: prevents lipid attachment to Ras (unsuccessful) Vemurafenib: inhibits downstream effectors |
|
Imatinib/gleevec |
Blocks BCR-abl kinase's substrate binding domain |
|
P61B-RafV600E |
Resistant to vemurafenib |