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36 Cards in this Set

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product rule

The probability of two independent events occurring simultaneously is the product of the individual probabilities


ex. dice p (one 4)=1/6


p(two 4s)=1/36

sum rule

The probability that one or the other of two mutually exclusive events will occur is the sum of their individual probabilities.


ex p(2 4s and 2 5s)= 1/36+1/36=1/18

chi-square test

A statistical test used to determine the probability of obtaining observed proportions by chance, under a specific hypothesis. χ2 test


The general situation is one in which observed results are compared with those predicted by a hypothesis


hypothesis will be rejected as false if there is a probability of less than 5 percent of observing a deviation from expectations at least as large as the one actually observed


χ2 = Σ (O – E)2/E for all classes

hybrid vigor

A situation in which an F1 is larger or healthier than its two different pure parental lines.

recombination

(1) In general, any process in a diploid or partly diploid cell that generates new gene or chromosomal combinations not previously found in that cell or in its progenitors. (2) At meiosis, the process that generates a haploid product of meiosis whose genotype is different from either of the two haploid genotypes that constituted the meiotic diploid.

meiotic recombination

Recombination from assortment or crossing over at meiosis.


Any meiotic process that generates a haploid product with new combinations of the alleles carried by the haploid genotypes that united to form the meiocyte.

recombinant

Refers to an individual organism or cell having a genotype produced by recombination.

polygene (quantitative trait locus [QLT])

A gene whose alleles are capable of interacting additively with alleles at other loci to affect a phenotype (trait) showing continuous distribution.

mitochondrial DNA (mtDNA):

The subset of the genome found in the mitochondrion, specializing in providing some of the organelle’s functions.

chloroplast DNA (cpDNA)

The small genomic component found in the chloroplasts of plants, concerned with photosynthesis and other functions taking place within that organelle.

uniparental existance

Inheritance pattern in which the progeny have the genotype and phenotype of one parent only, for example, inheritance of mitochrondrial genomes.

maternal inheritance



A type of uniparental inheritance in which all progeny have the genotype and phenotype of the parent acting as the female.

cytoplasmic segregation

Segregation in which genetically different daughter cells arise from a progenitor that is a cytohet.

law of independent assortment (Mendel’s second law):

Unlinked or distantly linked segregating gene pairs assort independently at meiosis.

dihybrid cross

A cross between two individuals identically heterozygous at two loci—for example, A B/a b X A B/a b.

dihybrid

A double heterozygote such as A/a · B/b.

chromosome map

A representation of all chromosomes in the genome as lines, marked with the positions of genes known from their mutant phenotypes, plus molecular markers. Based on analysis of recombinant frequency.

locus

The specific place on a chromosome where a gene is located

recombination map

A chromosome map in which the positions of loci shown are based on recombinant frequencies.

linked genes

The situation in which two genes are on the same chromosome as deduced by recombinant frequencies less than 50 percent.

crossing over

The exchange of corresponding chromosome parts between homologs by breakage and reunion

crossover product

Meiotic product cells with chromosomes that have engaged in a crossover

cis conformation

In a heterozygote having two mutant sites within a gene or within a gene cluster, the arrangement A1A2/a1a2

trans conformation

In a heterozygote with two mutant sites within a gene or gene cluster, the arrangement a1 +/+ a2

linkage map

A chromosome map; an abstract map of chromosomal loci that is based on recombinant frequencies.

centimorgan





The “distance” between two linked gene pairs where 1 percent of the products of meiosis are recombinant; a unit of distance in a linkage map.

recombinant frequency (RF)

The proportion (or percentage) of recombinant cells or individuals.

genetic map unit (m.u.)

A distance on the chromosome map corresponding to 1 percent recombinant frequency

three-point testcross

A testcross in which one parent has three heterozygous gene pairs

interference

A measure of the independence of crossovers from each other, calculated by subtracting the coefficient of coincidence from 1

coefficient of coincidence (c.o.c.)

The ratio of the observed number of double recombinants to the expected number

molecular marker

A DNA sequence variant that can be used to map an interesting phenotype to a specific region of DNA

single nucleotide polymorphism (SNP) (snip)

A nucleotide-pair difference at a given location in the genomes of two or more naturally occurring individuals

restriction fragment length polymorphism (RFLP)

A difference in DNA sequence between individuals or haplotypes that is recognized as different restriction fragment lengths. For example, a nucleotide-pair substitution can cause a restriction-enzyme-recognition site to be present in one allele of a gene and absent in another. Consequently, a probe for this DNA region will hybridize to different-sized fragments within restriction digests of DNAs from these two alleles

simple sequence length polymorphism (SSLP)

The existence in the population of individuals showing different numbers of copies of a short simple DNA sequence at one chromosomal locus

variable number tandem repeat (VNTR)

A chromosomal locus at which a particular repetitive sequence is present in different numbers in different individuals or in the two different homologs in one diploid individual