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11 Cards in this Set
- Front
- Back
H2 blockers (end in "tidine")
cimetidine ranitidine famtidine nizatidine |
- reversible block of H2 receptors leads to decreased H+ production by parietal cells
-used for peptic ulcer, gastritis, esophageal reflux -tox: cimetidine inhibits P450, and also has antiandrogenic effects (prolactin release, gynecomastia), it can also cross BBB to cause confusion, headaches, dizziness. can also cross placenta -both cimetidine and ranitidine decreased renal excretion of creatinine |
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proton pump inhibitors
omeprazole lansoprazole |
- irreversibly inhibit H/K ATPase in parietal cells
-used for peptic ulcer, gastritis, reflux, zollinger ellision syndrome |
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bismuth, sucralfate
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- bind to ulcer base providing physical protection and allows HCO3 secretion to reestablish pH gradient in mucous layer
- used for ulcer healing, traveler's diarrhea |
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triple therapy for H.pylori ulcers
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amoxicillin
metronidazole (or tetracycline) bismuth also use PPI |
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misoprostol
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- a prostaglandin (PGE) analog
-increases secretion of mucous barrier and decreases acid production - used for prevention of NSAID induced peptic ulcer, maintenance of patent ductus arteriosus tox: diarrhea |
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muscurinic antagonists
pirenzepine propantheline atropine |
- block M1 receptors on ECL cells thereby decreasing histamine production
-block M3 receptors on parietal cells therby decreasing H production -used for peptic ulcer tox: tachycardia, dry mouth, difficulty focusing eyes |
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anatcids
aluminum OH magnesium OH calcium carbonate |
- AlOH- constipation, hypophosphatemia, proximal muscle weakness, seizures
- MgOH- diarrhea, hyporeflexia, hypotension, cardiac arrest - CaCO3- hypercalcemia, rebound acid increase |
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infliximab
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- monoclonal Ab to TNF. anti inflammatory
-used for Chron's disease, RA - tox: resp infection, fever, hypotension, reactivation of latent TB |
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sulfasalazine
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- a combo of sulfapyridine and mesalamine. activated by colonic bacteria
- used for ulcerative collitis, chrons - tox: malaise, nausea, oligospermia, bone marrow suppression |
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ondansetron
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- serotonin antagonist. powerful central acting anti-emetic
- control vomiting postop and in pts undergoing chemo - tox: headache, constipation |
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metoclopramide
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- D2 receptor antagonist. increase resting tone, contractility, LES tone, motility
- used for diabetic & post surgery gastroparesis - tox: increase parkinsonian like effects, restlessness, nausea, diarrhea. DRUG INTERACTION WITH DIGOXIN & DIABETIC AGENTS. contraindicated in patients with small bowel obstruction |