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13 Cards in this Set
- Front
- Back
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Hemoglobin |
Found in RBC 4 polypeptides/O2 Sigmoidal in Dissociation Curve Transports O2 |
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Myoglobin |
Found in Heart and Muscles 1 polypeptide/O2 Hyperbolic in Dissociation Curve Stores O2 |
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2 config of hgb |
T form - low oxygen affinity (taut) R form - high oxygen affinity (relaxed) FeO2 in the middle, histidine proximal and distal binding |
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Allosteric Factor |
Shift to the right - dec affinity to o2 Shift to the left - inc affinity to o2 |
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Factors that cause shift to the right |
Inc CO2 Inc acidity Inc 23BPG Inc exercise Inc temperature |
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23BPG |
Makes hgb loose affinity to O2 Attaches to packets in deoxyhemoglobin From muscles (via glycolysis) Higher affinity in HbF Higher altitude, higher hgb, higher bpg, lower affinity to o2 |
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Bohr effect |
Deoxyhgb has higher affinity to proton than o2 Release of o2 enhance in higher ph or in increased pCO2 |
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Haldane effect |
Applies to oxyhgb Less o2 bound, more co2 attracted Polite way of releasing O2 |
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Enbryonal hgb |
Conception to first few month From yolk sac |
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Fetal hgb |
2a2y Few months to after birth Liver |
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Hemoglobin A |
Adult hgb A2b2 8th month onwards Marrow |
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Hemoglobin A2 |
A2d2 Shortly after birth Marrow 2% of total hgb in adults |
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Glycated Hgb (HbA1C) |
Glucose + erythrocytes = glycosylates lysine residues and amino terminals Inc in patients with DM Diagnosis: >6.5% For microvascular prev: <7% |
