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21 Cards in this Set
- Front
- Back
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Classification of HIV? |
SS RNA + |
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What gene encodes the capsid protein for HIV? |
gag |
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What is the capsid protein for HIV? |
p24 |
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What gene encodes proteins of the viral envelope? |
env |
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What does Gp120 do? |
Binds host cell in order for HIV to infect it |
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What is the 2 receptors necessary for Gp120 binding? |
CD4 surface receptors on T cells
CXCR4 or CXCR5 |
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What is Gp41's role? |
Viral fusion & entry into host cell |
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Which host cell types express CCR5 receptors? |
Macrophages, dendritic cells |
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Which host cell types Express CXCR4 receptors? |
CD4+ T cells |
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Once the viral RNA undergoes reverse transcription to DNA, which enzyme helps integrate it into host DNA? |
Integrase |
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What tests do we use for diagnosis of HIV? |
ELISA test first (high sensitivity) Western blot (high specificity) |
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Which pulmonary infection do we most commonly (and exclusively) see in AIDS patients? |
Pneumocystis jirovecii - a fungal infection |
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How do we visualize pneumocystis jirovecii? |
Silver stain |
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How do we treat pneumocystis pneumonia? |
TMP-SMX |
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HIV infections & their relative CD4 levels |
PCP (CD4 < 200)
Histoplasma (CD 4 < 150)
Mycobacterium avium complex (CD < 50) |
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What is a common cause of meningitis we see in AIDS patients? |
Croptococcal meningitis |
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What 2 neurologic problems in AIDS patients look very similar on MRI? |
Toxoplasmosis -- multiple ring-enhancing lesions
Primary CNS lymphoma -- Solitary ring enhancing lesion |
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What is the cause of PML in AIDS patients? |
JC Virus infection |
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Common causes of retinitis in AIDs patients? |
CMV, candida |
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What infections of the mouth do we commonly see in AIDS patients? |
Oral thrush -- candida Esophageal candidiasis -- candida (very painful)
Oral hairy leukoplakia -- EBV (won't scrape off like thrush) |
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Which malignancies do we often associate w/ HIV? And what do these malignancies all have in common? |
Viral origin!
Kaposi sarcoma (HHV-8) NHL (primary CNS lymphoma -- EBV association) Cervical/anal carcinoma (HPV 16, 18) |
