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10 Cards in this Set

  • Front
  • Back

Autoimmune Dse


Tissue Binding Antibodies and


Immune Complexes

SLE

Women


Childbearing


Joint Pain


Muscle Pain

SLE

Incidence of SLE

9:1 (Female to male ratio)

Genes affected in SLA

Human Leucocyte Antigen (HLA)

Environmental Factors of SLE

UV Light


Infections (EBV) -associated with cancer such as:




MEDICATIONS


SMOKING

EBV associated cancers

Infections (EBV) -associated with cancer such as: HODGKINS LYMPHOMANASOPHARYNGEAL CABURKITTS LYMPHOMA

Medications that causes SLE

Procainamide


Isoniazid


Methydopa


Hydralazine


PTU


Sulfonamides

PATHOPHYSIO OF SLE

FAILURE TO MAINTAIN SELF TOLERANCE

Most common clinical manifestation of SLE

Muscular 95%


Particilarly:


Arthralgia and Myalgia 95%

Factors that causes SLE

1. Genes - HLA


2. Environment


UV


Infections - EBV


3. Medications


PIMP HS


Procainamide


Isoniazid


Methydopa


PTU


Hydralazine


Sulfonamide


4. Smoking