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15 Cards in this Set
- Front
- Back
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Are T-cells ever soluble
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No- they are always membrane bound
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Where are TCRs derived from
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genetic recombination during maturation in the thymus before it has even encountered a complementary Ag
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What is significant about the cytoplasmic tails of TCRs
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They are short- so you need the CD3 complex to aid in signal transduction
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What are the V and C chains of a TCR made of?
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alpha and beta chains (minority have gamma and lambda chains)
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In a TCR, what is significant about those with lambda and gamma chains instead of the alpha beta chains?
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The Ag that binds in these chains isn't processed with MHC
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What composes the TCR complex?
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The TCR and CD3 components
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What makes up the CD3?
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It is an accessory molecule with a zeta zeta homodimer, (delta and epislon) and gamma and epsilon) heterodimers.
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What does the CD3 complex do?
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It participates in signal transduction (does not influence with Ag binding)
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Which T-cell accessory molecules aid in TCR adhesion?
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CD4/8, CD2(LFA-2), LFA-1, CD45R
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Which T-cell accessory molecules aid in TCR signal transduction?
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CD4/8, LFA-2, CD28, CTLA-4, CD45R, CD5
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Which T-cell accessory molecules are members of the IG superfamily?
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CD8, LFA-2, LFA-1(CD11a), CD28, CD45R
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Which T-cell accessory molecules are not members of the IG superfamily?
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LFA-1 (CD18), CTLA-4, CD5
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What is the Kd of TCRs compared to that of the Ag-Ab complex
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It is relatively weak.
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How do TCR compensate for their weak adhesion with Ag?
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They strengthen the bond with Cell Adhesion molecules (CD3 complex)
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When does activation of a T-cell occur?
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When the signal is fully sent.
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