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25 Cards in this Set
- Front
- Back
Similarities of all Rickettsiae
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1) Gram negative aerobic bacilli with weak LPS activity
2) Phospholipase A to escape phagosomes 3) Predilection for endothelial cells-pathogenesis due to endothelial damage 4) Obligate intracellular organisms 5) Diagnosis involves pt history, symptoms and serology. 6) Doxycycline is DOC |
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R. rickettsii
Clinical disease and manifestations |
1)Rocky mountain spotted fever
2) High fever, severe headache, rash spreading centripetally |
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R. rickettsii
Location |
SE Atlantic states and South central states
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R. rickettsii
Reservoir and vector |
R- East-Dog tick, West-Wood tick
V-same |
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R. rickettsii
Key info |
Most common in ages 5-9
Transovarial transmission in vector |
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R. rickettsii
Mortality Rate |
2-5% of Treated
20-40% untreated |
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R akari
Clinical disease and manifestations |
1) Rickettsial pox
2) Rash resembles chicken pox, eschar formation at bite site, fever severe headache |
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R. akari
Location |
Worldwide
NE United States |
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R. akari
Reservoir and Vector |
R- House mouse and mouse mite
V-Mouse mite |
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R. akari
Key Info |
1) Transovarial transmission in vector
2) Self limiting disease without treatment |
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R. akari
Mortality |
0%
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R. Prowazekii
Clinical disease and manifestations |
1) Epidemic or louse borne typhus
2) High fever, severe headache, rash spreading centrifugally sparing face, palms and soles; 3)Brill-zisser disease- reccurent |
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R. Prowazekii
Location |
Worldwide
Areas of crowding Poor sanitation |
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R. Prowazekii
Reservoir and Vector |
R-Humans
V-Human body louse |
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R. Prowazekii
Key information |
Transmission louse feces in wound
Vaccine available |
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R. Prowazekii
Mortality |
Untreated: 10% young, >50 years old 60-70%
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R Typhi
Disease and manifestations |
1) Endemic or murine typhus
2) Similar to epidemic typhus but milder symptoms, shorter course |
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R Typhi
Location |
Worldwide in humid areas
Urban cities/ports in US |
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R Typhi
Reservoir and vector |
R- Rat
V- Rat Flea |
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R Typhi
Mortality |
<1%
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O. tsutsugamushi
Disease and manifestations |
1) Scrub typhus
2) Eschar formation at site of bite, high fever, severe headache, rash spreading centrifugally |
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O. tsutsugamushi
Location |
World wide but most cases in East Asia/ Pacific islands, Few US cases reported
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O. tsutsugamushi
Reservoir and vector |
R- Rodents and mites
V-Chigger |
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O. tsutsugamushi
Key info |
1) Transovarial transmission in vector
2) Oftgen self limited but can be fatal if not treated |
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O. tsutsugamushi
Mortality rate |
~7% untreated;
None with treatment |