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42 Cards in this Set
- Front
- Back
T or F: Primary brian tumors are the most common solid tumors in the first decade of life
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TRUE
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T or F: Brain tumors don't generally cause mass effect
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FALSE
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What makes intrinsic brain tumors lethal
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invasion
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Where are most primary brain tumors?
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frontal lobes (and temporal)
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What are the 5 classes of brain tumors?
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Glial tumors
Meningeal tumors Peripheral nerve tumors Embryonal tumors Mets |
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What are some examples of glial tumors?
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astrocytomas, oligodendrogliomas, ependymomas
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What are some examples of meningeal tumors
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meningiomas
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What are some examples of peripheral nerve tumors?
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Schwannomas and neurofibromas
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What is an example of an embryonal tumor
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medulloblastoma
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Gliomas account for __% of all tumors and __% of malignant tumors of the brain
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40% of all tumors and 78% of malignant tumors
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What are the most common brain tumors of the brain?
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meningiomas
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What is the most common brain tumor in pts over 20 yo?
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glioblastomas
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What are the most common brain tumors in the first 2 decades of life?
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medulloblastoma
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Which tumor has the worst prognosis?
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glioblastomas
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Solid glioma that is well circumscribed, solid and cystic found in the cerebellum, hypothalamus, or optic nerve --> __
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pilocytic astrocytoma (WHO grade I)
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kids or adults more: pilocytic astrocytoma
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kids
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What are Rosenthal fibers and Eosinophilic granular bodies?
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brightly eosinophilic fibers seen in pilocytic astrocytoma that are remnants of degenerating axons, etc. indicative of a slow-growing process.
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Diffuse infiltration by cytologically atypical cells that are diffuse and hyperdense on T2 non-con MRI. What kind of glioma?
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Diffuse astrocytoma (WHO grade II)
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What is a grade III astrocytoma?
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Anaplastic astrocytoma
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Which astrocytoma has variable MRI appearance, and histo similar to diffuse astrocytoma with increased mitotic activity?
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Anaplastic astrocytoma
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Which is a grade II glimoa?
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Diffuse astrocytoma (WHO grade II)
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What is a grade IV astrocytoma?
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glioblastoma
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What astrocytoma presents as a single ring enhancing lesion on T1 MRI?
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glioblastoma
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Which astrocytoma has microvascular proliferation and necrosis(pseudopalisading)?
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glioblastoma
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Which gliomas are frequently calcified?
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oligodendrogliomas
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What is the signature molecular event of oligodendrogliomas?
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deletion of 1p and 19q (usually an unbalanced translocation)
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Which non-diffuse glioma typically grows in the cerebellum and spinal cord?
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ependymomas
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Which glioma can seed the CSF?
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ependymomas
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perivasuclar rosette -->
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ependymomas
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What is a useful diagnostic feature of meningioma on T1 MR w/ con?
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dural tail
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Which tumor takes up contrast the best?
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meningiomas
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What grade are typical meningiomas?
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WHO grade I
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What are some familial cancer syndromes?
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NF1, NF2, TSC, vHL, etc.
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Which PNS tumor expands the nerve sheath?
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Neurofibromas
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Bilateral acoustic schwannoma -->
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NF2
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Which tumor has biphasic (hypo and hyper cellular areas)?
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Schwannomas
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what are verocay bodies and where are they seen?
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nuclear palisades surrounding acellular zones seen in Schwanomas
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Which tumor occurs in the posterior fossa or cerebellum only?
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medulloblastoma
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What is the grade of medulloblastoma?
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WHO grade IV
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T or F: Medulloblastomas typically seed the CSF
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TRUE
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What is the most common "brain" tumor
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mets from somewhere else
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What are the most common sources of mets to the brain?
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lung, breast, skin (melanoma), kidney (rcc)
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