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22 Cards in this Set
- Front
- Back
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Bethanechol
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muscarinic selective agonist
no AChE hydrolysis |
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Muscarine
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from mushrooms
muscarinic selective agonist |
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Pilocarpine
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-muscarinic selective agonist
-glaucoma treatment (produces miosis) |
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Arecoline
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from Betel nut
muscarinic=nicotinic agonist |
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Effects of muscarinic agonists on heart
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normal to high doeses produce decreased HR via direct action on the heart
there is little effect on contractility |
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Effects of muscarinic agonists on blood vessels
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muscarinic receptor stimulation cuases synthesis & release of NO leading to vasodilation
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Too much of muscarinic agonist would produce parasympathomimetic or parasympatholytic effects?
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parasympathomimetic effects
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Edrophonium
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-AChE inhibitor
-used to diagnose myasthenia gravis -short acting |
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Donepezil
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-long lasting AChE inhibitor
-used to treat Alzheimer's |
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Physostigmine
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-AChE inhibitor
-tertiary amine w/ CNS activity -glaucoma treatment |
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Neostigmine
Pyridostigmine |
-AChE inhibitor
-no CNS activity -myasthenia gravis treatment |
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Carbaryl
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-AChE inhibitor
-carbamate -selectively toxic to insects |
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Malathion
Parathion |
-AChE inhibitor
-thiophosphates |
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Atropine
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-muscarinic blocker
-reveres muscarinic effects of AChE toxicity |
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Pralidoxime
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-AChE reactivator
-has higher affinity for organophosphate AChE inhibitor compared to AChE -it pulls the organophosphate off AChE protein |
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Ipratropium
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-muscarinic antagonist
-COPD treatment |
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Sarin
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-nerve gas
-AChE inhibitor -high degree of dermal & pulmonary absorption |
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This "---stigmine" has CNS activity.
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Physostigmine
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Used to diagnose myasthenia gravis
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Edrophonium
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Muscarinic agonist used to treat glaucoma
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Pilocarpine
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Belladonna alkaloids
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Atropine
Hyoscyamine Scopolamine |
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This belladonna alkaloid has marked CNS effects.
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Scopolamine
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