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26 Cards in this Set

  • Front
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Diabetes
Effects on Pregnancy:
Congenital malformation (2-4 fold)
Spontaneous abortion
Fetal growth disturbance (β-cell hyperplasia)
Sacral agenesis
Increased erythropoesis
Organomegaly
Macrosomia
Decreased surfactant production

Effects of Pregnancy (con.)
Unexplained fetal death (Uterine blood flow ↓ placenta function ↓)
Polyhydramnios
Intrapartum Risks
Asphyxia
Trauma; Shoulder dystocia
Neonatal hypoglycemia
Effects of pregnancy on epilepsy
Effects of Epilepsy

More difficulty in Disease control

Effect of Liver enzyme, Renal Perfusion

Increasing in circulating blood volume


The Reproductive Hormones may affect the
Reproductive health of woman with Epilepsy
Oestrogen Enhances Neuronal Excitability,
Lower Seizure Threshold
Progesterone Enhances Inhibition , Increases the
Seizure Threshold
Effects of epilepsy on pregnancy
Congenital Anomalies / Malformations (1.5-2.5 times)
Higher Risk in Women taking Combination Therapy

Teratogenic Anticonvulsants
Phenytoin, Carbamazepine, Valproic Acid…
Neural Tube Defects
Cardiac Defects
Interfere with maternal Vit.K producion
Early sign of congenital syphilis?
Early sign of congenital syphilis?
“barber’s pole” - umbilical cord
Hepatomegaly
Rhinitis – Syphilitic rhinitis (“snuffles”)
Cutaneous lesions – The rash of congenital syphilis usually appears one to two weeks after the rhinitis. It is maculopapular and consists of small, initially red or pink spots
Generalized lymphadenopathy
Late sign of congenital syphilis?
Late sign of congenital syphilis?
Facial features: Frontal bossing, saddle nose, short maxilla, protuberant mandible

Ophthalmologic: Interstitial keratitis, chorioretinitis, secondary glaucoma, corneal scarring, optic atrophy

Ears: Sensorineural hearing loss

Oropharynx: Hutchinson teeth, mulberry molars, perforation of hard palate
Cutaneous: Rhagades, gummas

Central nervous system: Intellectual disability, arrested hydrocephalus, seizures, optic atrophy, juvenile general paresis

Skeletal: Saber shins (anterior bowing of the tibia), Higoumenakis sign (enlargement of the sternoclavicular portion of the clavicle), Clutton joints (painless arthritis), scaphoid scapula
Effects of HIV on pregnancy?
The Incidence of Preterm Delivery, Intrauterine
Growth Retardation, Low Birth Weight -- Higher
(3-4 times) (In one study, 1988)

In Conclusion, A trend toward Small Babies in
Seropositive Women

Effect of HIV infection may be minimal when the
woman is Well
criteria for pre-eclampsia?
hypertension arises after 20 weeks gestation and is accompanied by one or more of the following:

Renal involvement:
Significant proteinuria – dipstick proteinuria subsequently confirmed by spot urine protein/creatinine ratio ≥ 30mg/mmol. In view of the close correlation between spot urine protein/creatinine ratio and 24 hour urine excretion, the latter is rarely required 21
Serum or plasma creatinine > 90 μmol/L
Oliguria

Haematological involvement
Thrombocytopenia
Haemolysis
Disseminated intravascular coagulation

Liver involvement
Raised serum transaminases
Severe epigastric or right upper quadrant pain.

Neurological involvement
Convulsions (eclampsia)
Hypereflexia with sustained clonus
Severe headache
Persistent visual disturbances (photopsia, scotomata, cortical blindness, retinal vasospasm)

Stroke

Pulmonary oedema

Fetal growth restriction

Placental abruption
what are the maternal and fetal outcomes of pre-eclampsia?
Maternal Outcome:
Cerebral Haemorrhage
Pulmonary edema
HELLP Syndrome (DIC)
Eclampsia …

Fetal Outcome:
Intrauterine Growth Retardation (IUGR)
Iatrogenic prematurity
Where are the majority of ectopic pregnancies?
Tubal – 98%

Ampulary – 80%

Isthmic -- 12%

Fimbrial -- 6%
WHat is the triad of symptoms in ectopic pregnancy?
Amenorrhea

Vaginal bleeding

Abdominal pain
What are the symptoms of ectopic if it's ruptured?
If rupture (Hemoperitoneum)

Shoulder Pain (phrenic nerve irritation)

Dyspnea, Vertigo, Syncope (Hemorrhage
hypovoleima)
What are the investigations for ectopic pregnancy?
Ultrasound
In ectopic pregnancy, serial β-hCG usually shows a failure to double in 48 hours or a static or slow increase or decrease
Laparoscopy


Culdocentesis pelvis through vagina (needle into p: non-clotting blood (hemoperitoneum)
management of ectopic
There is no place for expectant management in ectopic pregnancy

§ Treatment options include:
o Medical management with methotrexate
o Surgical management (usually laparoscopy)

Linear salpingectomy
Segmental resection
Salpingectomy
What are some contra indications for medical management?
Contraindication

Absolute – Breast feeding, immunodeficiency, alcoholism, liver
disease, sensitivity to MTX, active pul. Disease, peptic ulcer

Relative – GS > 3.5cm, Embryonic cardiac motion
causes of antepartum haemorrhage?
Causes

Placenta Previa*

Placental abruption*

Vasa Previa

Preterm cervical change

Preterm labor

Uterine rupture

Vulva / Vagina trauma, varicose vein

Cervical polyp, ectropion, cervicitis, carcinoma
Woman presents with antipartum haemorrhage:
painless what could it be?
Painful what could it be?
Painless - Placenta Previa

Painful - Placental abruption
risk factor for placenta previa?
Risk factor

Prior Previa

Prior Caesarean delivery

Multiparity

Advanced maternal age

Cocaine, Smoking
What is the management of placenta previa?
Management

IF Premature + Not severe  Close observation, Fluid,
Bed rest, Steroid

IF Term or Severe  Delivery (caesarean birth)
What is a
Couvelaire Uterus?
Couvelaire uterus (also known as uteroplacental apoplexy)[1] is a life threatening condition in which loosening of the placenta (abruptio placentae) causes bleeding that penetrates into the uterine myometrium forcing its way into the peritoneal cavity.
How do you manage a woman with antepartum haemorrhage of unknown cause?
How do you manage a woman with antepartum haemorrhage of unknown cause?
Risk factor for placental abruption
q
Risk Factors

Chronic Hyperternsion

Pre-eclampsia

Prior Abruption

Multiple gestation

Advanced Maternal age

Multiparity

Cocaine, Smoking

Chorioamnionitis

Trauma
mx for placental abruption
Management

Monitoring Vital signs (maternal & fetus),Fluid

Delivery for severe condition

Correct coagulopathy (DIC)
You're delivering a baby and it does the:
Turtle Sign (The delivered fetal head may retract
against the maternal perineum)

What does this mean?
Shoulder Dystocia
What are the risk factors for sholder dystocia?
Risk Factors

Multiparity

Macrosimia

Postterm gestation

Prior shoulder dystocia
Mx of shoulder dystocia:
Management

McRoberts Maneuver

Suprapubic Pressure

Rotational Maneuver

Delivery of Post. Arm

Zavanelli Maneuver

Intentional Fracture of fetal
clavicle
causes of PPH

Uterine Atony

Laceration of Lower Genital tract

Retained Placenta

Coagulation Defects

Amniotic Fluid Embolism (DIC)

Uterine inversion

Uterine Rupture