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302 Cards in this Set

  • Front
  • Back

A 54-year-old man with type 2 diabetes mellitus is found on annual review to have new vessel formation at the optic disc. Visual acuity in both eyes is not affected (6/9). Blood pressure is155/84 mmHg.



HbA1c 8.4%



What is the most important intervention to preserve vision in this patient?

Laser therapy






This patient has proliferative diabetic retinopathy and urgent referral to an ophthalmologist for panretinal photocoagulation is indicated. Good glycaemic control is obviously beneficial in the long-term but this patient needs intervention quickly to preserve his vision.

Optic neuritis usually occurs

over hours or days




so not really considered a cause of SUDDEN VISUAL LOSS

The most common causes of a sudden painless loss of vision are as follows:

ischaemic optic neuropathy (e.g. temporal arteritis or atherosclerosis)




occlusion of central retinal vein




occlusion of central retinal artery




vitreous haemorrhage




retinal detachment

Ischaemic optic neuropathy fxs

may be due to arteritis (e.g. temporal arteritis) or atherosclerosis (e.g. hypertensive, diabetic older patient)




due to occlusion of the short posterior ciliary arteries, causing damage to the optic nerve




altitudinal field defects are seen

Ischaemic optic neuropathy is associated with

arteritis e.g. temporal arteritis




or




atherosclerosis e.g. HTN, DM

Central retinal vein occlusion fxs

incidence increases with age




causes: glaucoma, polycythemia, HTN

which is more common central retinal artery or vein occlusion

vein

define polycythemia

increased RBCs




causes:


- increased RBCs or


- decreased plasma

difference b/w polycythemia and erythrocytosis

polycythemia = up rbc numbers




erythrocytosis = up rbc mass

tx for polycythemia

venesection

different types of polycythemia

1o




and 2o

1o polycythemia is due to

factors INTRINSIC to the RBC precursors

examples of 1o polycythemia

Polycythemia vera (PCV),


polycythemia rubra vera (PRV),


or erythremia




= UP RBC due to bone marrow problem




can also get up wbc and platelets

Polycythemia vera is classified as a

myeloproliferative disease




complication = acute leukemia (RARE)

2o polycythemia is caused by either

natural or artificial INCREASE IN EPO PRODUCTION

2o polycythemia due to natural increase in EPO production aka

physiologic polycythemia

Conditions which may result in a physiologically appropriate polycythemia include:

altitude related


hypoxic disease association


iatrogenic (e.g. phlebotomy)


genetic

pathological causes of 2o polycythemia

neoplasms


anabolic steroids


EPO r/t

Central retinal vein occlusion KEY Fx

severe retinal haemorrhages are usually seen on fundoscopy

Central retinal artery occlusion fxs

include afferent pupillary defect, 'cherry red' spot on a pale retina

Differentiating posterior vitreous detachment, retinal detachment and vitreous haemorrhage

Posterior vitreous detachment = flashing lights peripherally, floaters




Retinal detachment = peripheral shadow (moves in), curtain




Vitreous hemorrhage = large bleeds cause sudden loss visual loss, dark spots and floaters

A 63-year-old man presents to his GP complaining of pain in his right eye. On examination the sclera is red and the pupil is dilated with a hazy cornea. What is the most likely diagnosis?

Acute angle closure glaucoma

Red eye - glaucoma or uveitis?

glaucoma: severe pain, haloes, 'semi-dilated' pupil




uveitis: small, fixed oval pupil, ciliary flush

Red eye differentials

Acute angle closure glaucoma




Anterior uveitis




Scleritis




Conjunctivitis




Subconjunctival haemorrhage



Acute angle closure glaucoma fxs

severe pain (may be ocular or headache)




decreased visual acuity, patient sees haloes




semi-dilated pupil




hazy cornea

Anterior uveitis fxs

acute onset




pain




blurred vision and photophobia




small, fixed oval pupil,




ciliary flush/fullness

Scleritis fxs

severe pain (may be worse on movement) and tenderness




may be underlying autoimmune disease e.g. rheumatoid arthritis

AS is associated with

anterior uveitis

Conjunctivitis fxs

purulent discharge if bacterial, clear discharge if viral

Subconjunctival haemorrhage fxs

history of trauma or coughing bouts

A 71-year-old man presents with a burning sensation around his right eye. On examination an erythematous blistering rash can be seen in the right trigeminal distribution. What is the most likely diagnosis?

Herpes zoster ophthalmicus

Herpes zoster ophthalmicus definition

reactivation of varicella ZOSTER




in the opthalmic division of trigeminal

Herpes zoster ophthalmicus fxs

vesicular rash around eye +- the eye




Hutchinsons sign: rash on tip/side of nose (due to nasociliary branch of trigeminal) = strong risk factor for ocular involvement

Herpes zoster ophthalmicus mgmt

oral antiviral 7-10days, ideally within 72hrs




+- oral corticosteroids (for pain)




if eye involved = URGENT OPTHAL R/V

Herpes zoster ophthalmicus complications

ocular: conjunctivitis, keratitis, episcleritis, anterior uveitis




ptosis




post-herpetic neuralgia

bacterial conjunctivitis tx

bacterial conjunctivitis tx

Topical chloramphenicol

Conjunctivitis is the most common

eye problem presenting to primary care

bacterial conjunctivitis fxs

Purulent discharge




Eyes may be 'stuck together' in the morning)

Viral conjunctivitis fxs

Serous discharge




Recent URTI




Preauricular lymph nodes

Allergic conjunctivitis fxs

Bilateral symptoms




Itch is prominent




May be history of atopy




May be seasonal (due to pollen) or perennial (due to dust mite, washing powder or other allergens)

mgmt of infective conjunctivitis

normally settles without tx within 1-2/52




1st line: TOPICAL ABX e.g. chloramphenicol




2nd line and PREG = TOPICAL FUSIDIC ACID

with regards to infective conjunctivitis - whats done about contact lens, towels, and school

dont wear contacts during it




dont share towels




go to school

mgmt of allergic conjunctivitis

topical or systemic antihistamines




topical mast-cell stabilisers, e.g. Sodium cromoglicate and nedocromil

Fundoscopy reveals a number of yellow deposits in the left eye consistent with drusen formation. Similar changes but to a lesser extent are seen in the right eye. What is the most likely diagnosis?

Dry age-related macular degeneration

Drusen =

Dry macular degeneration

Age related macular degeneration




inV and dx

optical coherence tomography: provide cross sectional views of the macula




if neovascularisation is present fluorescein angiography is performed

Age related macular degeneration key is

degeneration of the macula

Traditionally two forms of macular degeneration are seen:

dry (geographic atrophy) macular degeneration: characterised by drusen - yellow round spots in Bruch's membrane




wet (exudative, neovascular) macular degeneration: characterised by choroidal neovascularisation. Leakage of serous fluid and blood can subsequently result in a rapid loss of vision. Carries worst prognosis

updated classfication of age related macular degen

early age related macular degeneration (non-exudative, age related maculopathy): drusen and alterations to the retinal pigment epithelium (RPE)




late age related macular degeneration (neovascularisation, exudative)

Age related macular degeneration risk factors

age: most patients are over 60 years of age




smoking




family history




more common in Caucasians




high cumulative sunlight exposure




female sex

Age related macular degeneration fxs

reduced visual acuity: 'blurred', 'distorted' vision, central vision is affected first




central scotomas




fundoscopy: drusen, pigmentary changes

in age related macular degeneration is central or peripheral vision lost first

CENTRAL VISION

general mgmt of age related macular degeneration

stop smoking




high dose of beta-carotene, vitamins C and E, and zinc may help to slow down visual loss for patients with established macular degeneration. Supplements should be avoided in smokers due to an increased risk of lung cancer

Dry macular degeneration tx

no medical tx




just stop smoking




next high dose beta carotene, vit C and E and zinc

Wet macular degeneration tx

photocoagulation




photodynamic therapy




anti-vascular endothelial growth factor (anti-VEGF) treatments: intravitreal ranibizumab

Which one of the following is the most common ocular manifestation of rheumatoid arthritis?

Keratoconjunctivitis sicca

Keratoconjunctivitis sicca is characterised by

dry, burning and gritty eyes caused by decreased tear production

Ocular manifestations of rheumatoid arthritis are common, with 25% of patients having eye problems

true

Ocular manifestations of RA

keratoconjunctivitis sicca (most common)




episcleritis (erythema)




scleritis (erythema and pain)




corneal ulceration




keratitis

RA drugs can cause what eye problems

steroid-induced cataracts




chloroquine retinopathy

dx

dx

Treated diabetic retinopathy




The fundus shows evidence of previous laser treatment.

diabetic retinopathy there are 2 types

1) non proliferative




2) proliferative

diabetic retinopathy - non proliferative type has 2 classfications, an old and a new one - describe the OLD one

old classfication:




Background retinopathy:


-microaneurysms (dots)


-blot haemorrhages (<=3)


-hard exudates




Pre-proliferative retinopathy


-cotton wool spots (soft exudates; ischaemic nerve fibres)


-> 3 blot haemorrhages


-venous beading/looping


-deep/dark cluster haemorrhages


-more common in Type I DM, treat with laser photocoagulation

diabetic retinopathy - non proliferative type has 2 classfications, an old and a new one - describe the NEW one

NEW CLASSIFICATION:




Mild NPDR


-1 or more microaneurysm




Moderate NPDR


-microaneurysms


-blot haemorrhages


-hard exudates


-cotton wool spots, venous beading/looping and intraretinal microvascular abnormalities (IRMA) less severe than in severe NPDR




Severe NPDR


-blot haemorrhages and microaneurysms in 4 quadrants


-venous beading in at least 2 quadrants


-IRMA in at least 1 quadrant

Proliferative retinopathy

retinal neovascularisation - may lead to vitrous haemorrhage




fibrous tissue forming anterior to retinal disc




more common in Type I DM, 50% blind in 5 years

DIABETIC RETINOPATHY associated maculopathy fxs

based on location rather than severity, anything is potentially serious




hard exudates and other 'background' changes on macula




check visual acuity




more common in Type II DM

Which one of the following is not a risk factor for primary open-angle glaucoma?

Hypermetropia

primary open-angle glaucoma is associated with

myopia

Acute angle closure glaucoma is associated with

hypermetropia

Glaucoma is a group disorders characterised by optic neuropathy due, in the majority of patients,

to raised intraocular pressure (IOP)

Primary open-angle glaucoma (POAG, also referred to as chronic simple glaucoma) risk factors

over 40yo (2%)


family history


black patients


myopia


hypertension


diabetes mellitus

Primary open-angle glaucoma fxs

peripheral visual field loss - nasal scotomas progressing to 'tunnel vision'




decreased visual acuity




optic disc cupping

age related macular degeneration vs primary open angle glaucoma

ARMD = central vision loss, central scotomas




POAG = peripheral vision, nasal scotomas

Horner's syndrome fxs:

miosis + ptosis + enophthalmos +/- anhydrosis

A patient of yours has been diagnosed with Horner's syndrome. Which of the following is most likely to be seen?

Miosis + ptosis + enophthalmos

heterochromia (difference in iris colour) is seen in congenital Horner's

true

Distinguishing between causes for horners based on anhydrosis

Central lesions


Anhydrosis of the face, arm and trunk


Causes:


-Stroke


-Syringomyelia


-Multiple sclerosis


-Tumour


-Encephalitis




Pre-ganglionic lesions


Anhydrosis of the face


Causes:


-Pancoast's tumour


-Thyroidectomy


-Trauma


-Cervical rib




Post-ganglionic lesions


No anhydrosis


Causes:


-Carotid artery dissection


-Carotid aneurysm


-Cavernous sinus thrombosis


-Cluster headache

dx

dx

Retinal detachment

dx

dx

Age-related macular degeneration

mgmt principle for 1o open angle glaucoma

most managed with eye drops to lower IOP = shown to prevent progressive loss of visual field

medical tx of 1o open angle glaucoma

1st line: Prostaglandin analogues (e.g. Latanoprost)




2nd line: BB e.g. timolol (not for asthma and heart block pxs)




others:




sympathomimetics e.g. brimonidine (no use if on MAOi/TCA)




carbonic anhydrase inhibitors (e.g. dorzolamide)




miotics e.g. pilocarpine

Prostaglandin analogues (e.g. Latanoprost) moa

Increases uveoscleral outflow




give once daily

Prostaglandin analogues (e.g. Latanoprost) AE

brown pigmentation of the iris

Beta-blockers (e.g. Timolol) moa

Reduces aqueous production

Beta-blockers (e.g. Timolol) CI

Should be avoided in asthmatics and patients with heart block

Sympathomimetics (e.g. brimonidine, an alpha2-adrenoceptor agonist) moa

Reduces aqueous production and increases outflow

Sympathomimetics (e.g. brimonidine, an alpha2-adrenoceptor agonist) CI

Avoid if taking MAOI or tricyclic antidepressants

Sympathomimetics (e.g. brimonidine, an alpha2-adrenoceptor agonist) AE

hyperaemia

Carbonic anhydrase inhibitors (e.g. Dorzolamide) moa

Reduces aqueous production

Carbonic anhydrase inhibitors (e.g. Dorzolamide) AE

Systemic absorption may cause sulphonamide-like reactions

Miotics (e.g. pilocarpine, a muscarinic receptor agonist) moa

Increases uveoscleral outflow

Miotics (e.g. pilocarpine, a muscarinic receptor agonist) AE

constricted pupil,


headache and


blurred vision

Primary open-angle glaucoma: management if refractory cases

Surgery in the form of a trabeculectomy may be considered in refractory cases.

Radioiodine treatment may lead to the development / worsening of

thyroid eye disease in up to 15% of patients with Grave's disease

An 84-year-old man presents with loss of vision in his left eye since the morning. He is otherwise asymptomatic and of note has had no associated eye pain or headaches. His past medical history includes ischaemic heart disease but he is otherwise well. On examination he has no vision in his left eye. The left pupil responds poorly to light but the consensual light reaction is normal. Fundoscopy reveals a red spot over a pale and opaque retina. What is the most likely diagnosis?

Central retinal artery occlusion

tx

tx

Papilloedema

Papilloedema




The following features may be observed during fundoscopy:

venous engorgement: usually the first sign




loss of venous pulsation: although many normal patients do not have normal pulsation




blurring of the optic disc margin




elevation of optic disc




loss of the optic cup




Paton's lines: concentric/radial retinal lines cascading from the optic disc

Causes of papilloedema

space-occupying lesion: neoplastic, vascular




malignant hypertension




idiopathic intracranial hypertension




hydrocephalus




hypercapnia




Rare causes include:


hypoparathyroidism and hypocalcaemia


vitamin A toxicity

Malignant hypertension is

extremely high blood pressure that develops rapidly and causes some type of organ damage




blood pressure that's typically above 180/120.




one main cause is stopping antiHTN meds, other common causes:




autonomic hyperactivity, collagen-vascular diseases, drug use (particularly stimulants, especially cocaine and amphetamines and theirsubstituted analogues), glomerulonephritis, head trauma, neoplasias, preeclampsia and eclampsia, and renovascular hypertension

Colours, especially red, seem 'washed-out'. dx

Optic neuritis

Optic neuritis classic sxs

Visual loss, eye pain and red desaturation

key fx with optic neuritis

red desaturation ie cant really see red

Optic neuritis causes

MS


DM


syphilis

Optic neuritis fxs

unilateral decrease in visual acuity over hours or days




poor discrimination of colours, 'red desaturation'




pain worse on eye movement




relative afferent pupillary defect




central scotoma

Optic neuritis mgmt

high-dose steroids




recovery usually takes 4-6 weeks

Optic neuritis prognosis

MRI: if > 3 white-matter lesions, 5-year risk of developing multiple sclerosis is c. 50%

Pituitary tumour associated visual field defect:

Bitemporal hemianopia, upper quadrant defect

Primary open angle glaucoma in right eyeassociated visual field defect:

Unilateral peripheral visual field loss

Patient who has had an extensive stroke with right-sided hemiplegiaassociated visual field defect:

Right homonymous hemianopia

the homonymous hemianopia is always on what side as paresis

on the SAME SIDE as the paresis

dx

dx

Hordeolum externum

Eyelid problems commonly encountered include:

blepharitis: inflammation of the eyelid margins typically leading to a red eye




stye: infection of the glands of the eyelids




chalazion (Meibomian cyst)




entropion: in-turning of the eyelids




ectropion: out-turning of the eyelids

Different types of stye are recognised:

external (hordeolum externum):


-infection (usually staphylococcal) of the glands of Zeis (sebum producing) or glands of Moll (sweat glands).




internal (hordeolum internum):


- infection of the Meibomian glands. May leave a residual chalazion (Meibomian cyst)

STYE mgmt

includes hot compresses and analgesia




if assoc conjunctivitis = ABX

A chalazion (Meibomian cyst) is

a retention cyst of the Meibomian gland. It presents as a firm painless lump in the eyelid.




The majority of cases resolve spontaneously but some require surgical drainage

dx

dx

Retinal detachment

A 35-year-old man presents with visual problems. He has had very poor vision in the dark for a long time but is now worried as he is developing 'tunnel vision'. He states his grandfather had a similar problem and was registered blind in his 50's. What is the most likely diagnosis?

Retinitis pigmentosa

px developoing night blindness + tunnel vision - dx

Retinitis pigmentosa

Retinitis pigmentosa mainly affects the

peripheral retina resulting in tunnel vision

Retinitis pigmentosa fxs

night blindness is often the initial sign




funnel vision (the preferred term for tunnel vision)




fundoscopy: black bone spicule-shaped pigmentation in the peripheral retina, mottling of the retinal pigment epithelium

Retinitis pigmentosa is associated with other diseases - which ones

Refsum disease: cerebellar ataxia, peripheral neuropathy, deafness, ichthyosis




Usher syndrome




abetalipoproteinemia




Lawrence-Moon-Biedl syndrome




Kearns-Sayre syndrome




Alport's syndrome

dx

dx

Fundus showing changes secondary to retinitis pigmentosa

Bitemporal hemianopia fxs

temporal hemianopia




lesion of optic chiasm




upper quadrant defect > lower quadrant defect = inferior chiasmal compression, commonly a pituitary tumour




lower quadrant defect > upper quadrant defect = superior chiasmal compression, commonly a craniopharyngioma

Homonymous hemianopia fxs

incongruous defects: lesion of optic tract




congruous defects: lesion of optic radiation or occipital cortex




macula sparing: lesion of occipital cortex




nb A congruous defect simply means complete or symmetrical visual field loss and conversely an incongruous defect is incomplete or asymmetric. Please see the link for an excellent diagram.

Visual field defects




The main points for the exam are:

left homonymous hemianopia means visual field defect to the left, i.e. Lesion of right optic tract




homonymous quadrantanopias: PITS (Parietal-Inferior, Temporal-Superior)




incongruous defects = optic tract lesion;




congruous defects = optic radiation lesion or occipital cortex

incongruous defects = optic tract lesion;




congruous defects = optic radiation lesion or occipital cortex

true

Smoking is the most important modifiable risk factor for the development of

thyroid eye disease

A 35-year-old female who has recently being diagnosed with Grave's disease presents for review 3 months after starting a 'block and replace' regime with carbimazole and thyroxine. She is concerned about developing thyroid eye disease. What is the best way that her risk of developing thyroid eye disease can be reduced?

Stop smoking

mgmt of thyroid eye disease

topical lubricants may be needed to help prevent corneal inflammation caused by exposure




steroids




radiotherapy




surgery

Thyroid eye disease affects between 25-50% of patients with Graves' disease.

true

Anterior uveitis mgmt

urgent review by ophthalmology




cycloplegics (dilates the pupil which helps to relieve pain and photophobia) e.g. Atropine, cyclopentolate




steroid eye drops

Anterior uveitis is one of the important differentials of a red eye. It is also referred to as iritis.




its associated with

AS


reactive arthritis


IBD (both)


Bechets dis

diagnosis of acute glaucoma. Which of the following should be the aims of treatment?

Reducing aqueous secretion + inducing pupillary constriction

difference b/w anterior uveitis and acute glaucoma in relation to the meds used to manage the pupil

anterior uveitis - meds for dilating the pupil




acute glaucoma - meds used for constricting the pupil

In acute angle closure glaucoma (AACG) there is a rise in IOP secondary

to an impairment of aqueous outflow.

Factors predisposing to acute angle closure glaucomaAACG include

hypermetropia (long-sightedness)


pupillary dilatation


lens growth associated with age

Acute angle closure glaucoma fxs

severe pain: may be ocular or headache




decreased visual acuity




symptoms worse with mydriasis (e.g. watching TV in a dark room)




hard, red eye




haloes around lights




semi-dilated non-reacting pupil




corneal oedema results in dull or hazy cornea




systemic upset may be seen, such as nausea and vomiting and even abdominal pain

Acute angle closure glaucoma mgmt

urgent referral to an ophthalmologist




management options include reducing aqueous secretions with acetazolamide and inducing pupillary constriction with topical pilocarpine

normal range for intraocular pressure?

10-21 mmHg

dx

dx

Sebaceous cyst

dx

dx

normal

dx

dx

Background retinopathy

A 45-year-old woman with Graves' disease comes for review. She has recently been diagnosed with thyroid eye disease and is being considered for radiotherapy. Over the past three days her right eye has become red and painful. On examination there is proptosis and erythema of the right eye. Visual acuity is 6/9 in both eyes. What complication is she most likely to have developed?

Exposure keratopathy

Exposure keratopathy due to

radiotherapy for graves dis

Ptosis + dilated pupil =

third nerve palsy

ptosis + constricted pupil =

Horner's

A 64-year-old woman presents with bilateral sore eyelids. She also complains of her eyes being dry all the time. On examination her eyelid margins are erythematous at the margins but are not swollen. Of the given options, what is the most appropriate initial management?

Hot compresses + mechanical removal of lid debris

Blepharitis is

inflammation of the eyelid margins

Blepharitis causes

either




meibomian gland dysfunction (common, posterior blepharitis) or




seborrhoeic dermatitis/staphylococcal infection (less common, anterior blepharitis)





Blepharitis is also more common in patients with rosacea

true

The meibomian glands secrete

oil on to the eye surface to prevent rapid evaporation of the tear film

Any problem affecting the meibomian glands (as in blepharitis) can hence cause drying of the eyes which in turns leads to

irritation

Blepharitis fxs

symptoms are usually bilateral




grittiness and discomfort, particularly around the eyelid margins




eyes may be sticky in the morning




eyelid margins may be red. Swollen eyelids may be seen in staphylococcal blepharitis




styes and chalazions are more common in patients with blepharitis




secondary conjunctivitis may occur

Blepharitis mgmt

hot compresses




mechanical removal of debri




if dry eyes = artificial tears

dx

dx

Branch retinal vein occlusion




Fundoscopy shows flame-shaped haemorrhages on the temporal aspect of the fundus and subretinal haemorrhages

A 67-year-old man presents as he has developed a painful blistering rash around his right eye. On examination a vesicular rash covering the right trigeminal nerve dermatome is seen. Currently he has no eye symptoms or signs. Which one of the following is most likely to predict future eye involvement?

Presence of the rash on the tip of his nose




This is Hutchinson's sign which is strongly predictive for ocular involvement.

A 43-year-old man with a history of chronic back pain presents to his GP complaining of pain in his left eye and photophobia. On examination the pupil is small, oval shaped and associated with ciliary congestion. What is the most likely diagnosis?

Anterior uveitis

Red eye - glaucoma or uveitis?

glaucoma: severe pain, haloes, 'semi-dilated' pupil




THE GLOC is associated with HELO - COD




uveitis: small, fixed oval pupil, ciliary flush




- UV light makes you squint = small fixed pupils, you need fluid to keep cool, ciliary makes fluid

dx

dx

Macular degeneration

A 68-year-old man with a history of type 2 diabetes mellitus presens with worsening eye sight. Mydriatic drops are applied and fundoscopy reveals pre-proliferative diabetic retinopathy. A referral to ophthalmology is made. Later in the evening whilst driving home he develops pain in his left eye associated with decreased visual acuity. What is the most likely diagnosis?

Acute angle closure glaucoma

Mydriatic drops are a known precipitant of

acute angle closure glaucoma

Mydriatic drops are applied and fundoscopy reveals pre-proliferative diabetic retinopathy




he develops pain in his left eye associated with decreased visual acuity




dx

Acute angle closure glaucoma

A 60-year-old woman who has recently started treatment for polymyalgia rheumatica presents with a five day history of headaches and reduced vision on the right side since this morning There is no eye pain but the there is a 'large, dark shadow' covering the superior visual field on the right side. On examination she has a tender, palpable right temporal artery. What is the most likely explanation for the reduced vision?

Anterior ischemic optic neuropathy

Temporal arteritis is large vessel vasculitis which overlaps with

polymyalgia rheumatica (PMR)

Temporal arteritis histology findings

changes which characteristically 'skips' certain sections of affected artery whilst damaging others.

with temporal arteritis you can get visual disturbances how

secondary to anterior ischemic optic neuropathy

A 6-year-old boy is brought to surgery as mum has noticed redness of his right eye. When assessing the child which one of the following features would be most associated with a viral aetiology?

Preauricular lymph nodes = viral conjunctivitis

A 54-year-old woman presents with a persistent watery left eye for the past 4 days. On examination there is erythema and swelling of the inner canthus of the left eye. What is the most likely diagnosis?

Dacryocystitis

Dacryocystitis definition

infection of the lacrimal sac

Dacryocystitis fxs

watering eye (epiphora)




swelling and erythema at the inner canthus of the eye

Dacryocystitis mgmt

systemic abx




if px has assoc periorbital cellulitis - give IV abx

Congenital lacrimal duct obstruction

affects around 5-10% of newborns. It is bilateral in around 20% of cases




fxs


watering eye (even if not crying)


secondary infection may occur




Symptoms resolve in 99% of cases by 12 months of age

Lacrimal duct problems

Dacryocystitis




Congenital lacrimal duct obstruction

At what age would the average child be expected to have visual acuity similar to that of an adult?

2 years

vision tests which may be performed when assessing children:

Birth = Red reflex




6 weeks = Fix and follow to 90 degrees (e.g. Red ball 90cm away)




3 months = Fix and follow to 180 degrees, No squint




12 months = Can pick up 'hundreds and thousands' with pincer grip




> 3 years = Letter matching test




> 4 years = Snellen charts &


Ishihara plates for colour vision

A 24-year-old man presents to the emergency department complaining of left eye pain. He has not been able to wear his contact lenses for the past 24 hours due to the pain. He describes the pain as severe and wonders whether he has 'got something stuck in his eye'. On examination there is diffuse hyperaemia of the left eye. The left cornea appears hazy and pupillary reaction is normal. Visual acuity is reduced on the left side and a degree of photophobia is noted. A hypopyon is also seen. What is the most likely diagnosis?

Keratitis

Keratitis describes

inflammation of the cornea

Keratitis causes

infxn




enviro

keratitis fxs

red eye: pain and erythema




photophobia




foreign body, gritty sensation




hypopyon may be seen

Infective causes for keratitis

viral: herpes simplex keratitis




bacterial: typically Staphylococcus aureus. Pseudomonas aeruginosa is seen in contact lens wearers




fungal




amoebic: acanthamoebic keratitis




parasitic: onchocercal keratitis ('river blindness')



hypopyon

hypopyon

exudate in the anterior chamber of the eye

enviro causes of keratitis

hotokeratitis: e.g. welder's arc eye




exposure keratitis




contact lens acute red eye (CLARE)

dx

dx

Hypertensive retinopathy

Hypertensive retinopathy




Keith-Wagener classification of hypertensive retinopathy

I =


Arteriolar narrowing and tortuosity


Increased light reflex - silver wiring




II = Arteriovenous nipping




III =


Cotton-wool exudates


Flame and blot haemorrhages




IV =


Papilloedema

A 31-year-old man presents with a painful swelling of his right upper eyelid for the past 3 days. On lifting the eyelid a yellow head pointing at the lid margin can be seen. What is the most appropriate management?

Analgesia + warm compresses




dx = stye

dx

dx

Left-sided ectropion




eyelid turned out

A 35-year-old man presents with right eye pain which is worse on movement. Examination reveals a relative afferent pupillary defect. Which one of the following is the most likely cause of his problems?

Multiple sclerosis

eye pain which is worse on movement




relative afferent pupillary defect.




dx

optic neuritis secondary to multiple sclerosis

A 64-year-old woman with type 2 diabetes mellitus presents as she has started to bump into things since the morning. Her medications include metformin, simvastatin and aspirin. Over the previous two days she had noticed numerous 'dark spots' over the vision in her right eye. Examination reveals she has no vision in her right eye. The red reflex on the right side is difficult to elicit and you are unable to visualise the retina on the right side during fundoscopy. Examination of the left fundus reveals changes consistent with pre-proliferative diabetic retinopathy. What is the most likely diagnosis?

Vitreous haemorrhage

Darth Vader is from the Dark Side

Dark Spots is associated with Vitreous hemorrhage



This diabetic man complained of worsening of his vision. dx

This diabetic man complained of worsening of his vision. dx

Proliferative retinopathy

A 54-year-old man is noted to have papilloedema on examination. Which one of the following may be responsible?

Hypercapnia

A 40-year-old man presents with bilateral dry, gritty eyes. A diagnosis of blepharitis is considered. Which one of the following is least likely to be associated with blepharitis?

Viral upper respiratory tract infection

Whats the most likely cause of optic neuritis

MS

Which one of the following is least likely to be associated with blepharitis?

Viral upper respiratory tract infection

A 23-year-old female presents with recurrent headaches. Examination of her cranial nerves reveals the right pupil is 3 mm whilst the left pupil is 5 mm. The right pupil constricts to light but the left pupil is sluggish. Peripheral neurological examination is unremarkable apart from difficult to elicit knee and ankle reflexes. What is the most likely diagnosis?

Holmes-Adie syndrome

Holmes-Adie pupil

is a benign condition most commonly seen in women. It is one of the differentials of a dilated pupil.

Holmes-Adie pupil

is a benign condition most commonly seen in women. It is one of the differentials of a dilated pupil.

Holmes-Adie pupil fxs

unilateral in 80% of cases



dilated pupil



once the pupil has constricted it remains small for an abnormally long time


slowly reactive to accommodation but very poorly (if at all) to light

Holmes-Adie pupil

is a benign condition most commonly seen in women. It is one of the differentials of a dilated pupil.

Holmes-Adie pupil fxs

unilateral in 80% of cases



dilated pupil



once the pupil has constricted it remains small for an abnormally long time


slowly reactive to accommodation but very poorly (if at all) to light

Holmes-Adie syndrome


association of

absent ankle/knee reflexes

A 65-year-old man with a history of primary open-angle glaucoma presents with sudden painless loss of vision in his right eye. On examination of the right eye the optic disc is swollen with multiple flame-shaped and blot haemorrhages. What is the most likely diagnosis?

Occlusion of the central retinal vein

Central retinal vein occlusion - fxs

sudden painless loss of vision,



severe retinal haemorrhages on fundoscopy

Adverse effects include brown pigmentation of the iris

The correct answer is Latanoprost

Adverse effects include brown pigmentation of the iris

The correct answer is Latanoprost

Should be avoided in patients taking MAOI drugs


Brimonidine

Causes pupillary constriction, blurred vision and headaches

Pilocarpine

A mother brings her 8-week-old child in for review. Since birth his right eye has been watering. His symptoms have got worse over the past few days after he picked up a mild viral illness. Clinical examination is unremarkable. What is the most appropriate action?

Teach nasolacrimal duct massage

A mother brings her 8-week-old child in for review. Since birth his right eye has been watering. His symptoms have got worse over the past few days after he picked up a mild viral illness. Clinical examination is unremarkable. What is the most appropriate action?

Teach nasolacrimal duct massage

Nasolacrimal duct obstruction



Most common cause of

persistent watery eye in an infant

Nasolacrimal duct obstruction



Most common cause of

persistent watery eye in an infant



caused by an imperforate membrane, usually at the lower end of the lacrimal duct

Nasolacrimal duct obstruction



Most common cause of

persistent watery eye in an infant



caused by an imperforate membrane, usually at the lower end of the lacrimal duct



Around 1 in 10 infants have symptoms at around one month of age

Management for Nasolacrimal duct obstruction


teach parents to massage the lacrimal duct



symptoms resolve in 95% by the age of one year. Unresolved cases should be referred to an ophthalmologist for consideration of probing, which is done under a light general anaesthetic

A 70-year-old man is investigated for blurred vision. Fundoscopy reveals drusen, retinal epithelial and macular neovascularisation. A diagnosis of age related macular degeneration is suspected. What is the most appopriate next investigation?

Fluorescein angiography

A 25-year-old woman presents with a one-day history of a painful and red left eye. She describes how her eye is continually streaming tears. On examination she exhibits a degree of photophobia in the affected eye and fluorescein staining demonstrates a small, feathery area of abnormal uptake. Visual acuity is 6/6 in both eyes. What is the most appropriate management?

Refer immediately to ophthalmology

A 25-year-old woman presents with a one-day history of a painful and red left eye. She describes how her eye is continually streaming tears. On examination she exhibits a degree of photophobia in the affected eye and fluorescein staining demonstrates a small, feathery area of abnormal uptake. Visual acuity is 6/6 in both eyes. What is the most appropriate management?

Refer immediately to ophthalmology


This patient may have a corneal abrasion or a dendritic corneal ulcer, particularly given the photophobia. The feathery pattern however points more towards a herpes simplex keratitis. Such a patient should be reviewed immediately by an ophthalmologist. Giving a topical steroid in this situation could be disastrous as it may worsen the infection.

...

Herpes simplex keratitis most commonly presents with a

dendritic corneal ulcer

Herpes simplex keratitis most commonly presents with a

dendritic corneal ulcer

Herpes simplex keratitis



Fxs

red, painful eye


photophobia


epiphora


visual acuity may be decreased


fluorescein staining may show an epithelial ulcer

Herpes simplex keratitis



Management

immediate referral to an ophthalmologist



topical aciclovir

A 54-year-old female presents to the Emergency Department concerned about double vision. She is noted to have exophthalmos and conjunctival oedema on examination and a diagnosis of thyroid eye disease is suspected. What can be said regarding her thyroid status?

Thyroid eye disease affects between 25-50% of patients with Graves' disease.



Pathophysiology


it is thought to be caused by an autoimmune response against an autoantigen, possibly the TSH receptor retro-orbital inflammation


the inflammation results in glycosaminoglycan and collagen deposition in the muscles



Prevention


smoking is the most important modifiable risk factor for the development of thyroid eye disease


radioiodine treatment may increase the inflammatory symptoms seen in thyroid eye disease. In a recent study of patients with Graves' disease around 15% developed, or had worsening of, eye disease. Prednisolone may help reduce the risk



Features


the patient may be eu-, hypo- or hyperthyroid at the time of presentation


exophthalmos


conjunctival oedema


optic disc swelling


ophthalmoplegia


inability to close the eye lids may lead to sore, dry eyes. If severe and untreated patients can be at risk of exposure keratopathy



Management


topical lubricants may be needed to help prevent corneal inflammation caused by exposure


steroids


radiotherapy


surgery



Monitoring patients with established thyroid eye disease



For patients with established thyroid eye disease the following symptoms/signs should indicate the need for urgent review by an ophthalmologist (see EUGOGO guidelines):


unexplained deterioration in vision


awareness of change in intensity or quality of colour vision in one or both eyes


history of eye suddenly 'popping out' (globe subluxation)


obvious corneal opacity


cornea still visible when the eyelids are closed


disc swelling


Next question

A 69-year-old man presents with blurred vision. His GP suspects a diagnosis of primary open-angle glaucoma (POAG). Which one of the following features would be most consistent with a diagnosis of POAG?

Peripheral visual field loss

A 39-year-old woman with a history of rheumatoid arthritis presents with a two day history of a red right eye. There is no itch or pain. Pupils are 3mm, equal and reactive to light. Visual acuity is 6/5 in both eyes. What is the most likely diagnosis?

Episcleritis

Scleritis is painful, episcleritis is not painful

True

Ocular manifestations of RA

keratoconjunctivitis sicca (most common)


episcleritis (erythema)


scleritis (erythema and pain)


corneal ulceration


keratitis

Ocular manifestations of RA

keratoconjunctivitis sicca (most common)


episcleritis (erythema)


scleritis (erythema and pain)


corneal ulceration


keratitis

A 65-year-old man presents with an acute, painful red eye. Which one of the following features would not support a diagnosis of acute angle closure glaucoma?

Small pupil

Ocular manifestations of RA

keratoconjunctivitis sicca (most common)


episcleritis (erythema)


scleritis (erythema and pain)


corneal ulceration


keratitis

A 65-year-old man presents with an acute, painful red eye. Which one of the following features would not support a diagnosis of acute angle closure glaucoma?

Small pupil

A 70-year-old woman presents with loss of vision in her left eye. For the past two weeks she has painful frontal headaches and has been feeling generally lethargic. On examination visual acuity is 6/9 in the right eye but on the left side only hand movements can be made seen. Fundoscopy of the left side reveals a pale and oedematous optic disc. What is the most likely diagnosis?.

Temporal arteritis

Ocular manifestations of RA

keratoconjunctivitis sicca (most common)


episcleritis (erythema)


scleritis (erythema and pain)


corneal ulceration


keratitis

A 65-year-old man presents with an acute, painful red eye. Which one of the following features would not support a diagnosis of acute angle closure glaucoma?

Small pupil

A 70-year-old woman presents with loss of vision in her left eye. For the past two weeks she has painful frontal headaches and has been feeling generally lethargic. On examination visual acuity is 6/9 in the right eye but on the left side only hand movements can be made seen. Fundoscopy of the left side reveals a pale and oedematous optic disc. What is the most likely diagnosis?.

Temporal arteritis

A 22-year-old man is referred to urology with possible urinary retention. He is passing huge amounts of urine. Post void bladder ultrasound is normal.

The correct answer is Lower bitemporal hemianopia



This patient has diabetes insipidus due to a craniopharyngioma. This causes a lower bitemporal hemianopia.

diagnosis of herpes zoster ophthalmicus is made and an urgent referral to ophthalmology is made. What treatment is she most likely to be given?

Oral aciclovir

Which one of the following conditions would most predispose you to developing anterior uveitis?

Crohn's disease

A 65-year-old woman presents with visual problems. She suffers from rheumatoid arthritis, depression and takes medication to control her blood pressure. Over the past few days she has been getting troublesome headaches and blurred vision but today has noted a marked reduction in vision in the right eye. On examination her right eye is red, has a sluggish pupil and a corrected visual acuity 6/30. Her medication has recently been changed. Which one of the following drugs is most likely to have precipitated this event?

Amitriptyline


Drugs which may precipitate acute glaucoma include

anticholinergics and tricyclic antidepressants


Drugs which may precipitate acute glaucoma include

anticholinergics and tricyclic antidepressants

dry age-related macular degeneration is reviewed. Unfortunately her eyesight has deteriorated over the past six months. She has never smoked and is taking antioxidant supplements. What is the most appropriate next step?

Explain no other medical therapies currently available

A 34-year-old woman presents complaining of headaches. Examination of her pupils using a light shone alternately in each eye reveals that when the light is shone in the right eye both pupils constrict but when the light source immediately moves to the left eye both eyes appear to dilate.



What is the most likely diagnosis?

Left optic neuritis



This is the 'swinging light test' and reveals a relative afferent pupillary defect. As there is a defect in the afferent nerve on the left side the pupils constrict less than normal, giving the impression of dilation.



Given her age, multiple sclerosis causing optic neuritis is the likely underlying diagnosis. Optic neuritis typically causes a dull ache in the region of the eye which is aggravated by movement

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect causes

retina: detachment



optic nerve: optic neuritis e.g. multiple sclerosis

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect causes

retina: detachment



optic nerve: optic neuritis e.g. multiple sclerosis

Pathway of pupillary light reflex

afferent: retina optic nerve lateral geniculate body midbrain



efferent: Edinger-Westphal nucleus (midbrain) oculomotor nerve

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect causes

retina: detachment



optic nerve: optic neuritis e.g. multiple sclerosis

Pathway of pupillary light reflex

afferent: retina optic nerve lateral geniculate body midbrain



efferent: Edinger-Westphal nucleus (midbrain) oculomotor nerve

A 74-year-old man presents with a severe throbbing headache on the right side of his head. He has now had this pain for around 6-7 days but reports no obvious trigger. There have been no visual disturbances or episodes of limb weakness. Neurological examination is unremarkable. The right side of his head is tender to touch but he cannot remember falling. Given the likely diagnosis what is the most important initial step?

Give high-dose oral prednisolone




Dx temporal arteritis

Each one of the following is a cause of a mydriatic pupil, except:

Argyll-Robertson pupil

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect causes

retina: detachment



optic nerve: optic neuritis e.g. multiple sclerosis

Pathway of pupillary light reflex

afferent: retina optic nerve lateral geniculate body midbrain



efferent: Edinger-Westphal nucleus (midbrain) oculomotor nerve

A 74-year-old man presents with a severe throbbing headache on the right side of his head. He has now had this pain for around 6-7 days but reports no obvious trigger. There have been no visual disturbances or episodes of limb weakness. Neurological examination is unremarkable. The right side of his head is tender to touch but he cannot remember falling. Given the likely diagnosis what is the most important initial step?

Give high-dose oral prednisolone




Dx temporal arteritis

Each one of the following is a cause of a mydriatic pupil, except:

Argyll-Robertson pupil

Argyll-Robertson pupil is one of the classic pupillary syndrome. It is sometimes seen in neurosyphilis and is often said to be the prostitute's pupil - accommodates but doesn't react. Another mnemonic used for the Argyll-Robertson Pupil (ARP) is Accommodation Reflex Present (ARP) but Pupillary Reflex Absent (PRA)

Features


small, irregular pupils


no response to light but there is a response to accommodate



Causes


diabetes mellitus


syphilis

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect causes

retina: detachment



optic nerve: optic neuritis e.g. multiple sclerosis

Pathway of pupillary light reflex

afferent: retina optic nerve lateral geniculate body midbrain



efferent: Edinger-Westphal nucleus (midbrain) oculomotor nerve

A 74-year-old man presents with a severe throbbing headache on the right side of his head. He has now had this pain for around 6-7 days but reports no obvious trigger. There have been no visual disturbances or episodes of limb weakness. Neurological examination is unremarkable. The right side of his head is tender to touch but he cannot remember falling. Given the likely diagnosis what is the most important initial step?

Give high-dose oral prednisolone




Dx temporal arteritis

Each one of the following is a cause of a mydriatic pupil, except:

Argyll-Robertson pupil

Argyll-Robertson pupil is one of the classic pupillary syndrome. It is sometimes seen in neurosyphilis and is often said to be the prostitute's pupil - accommodates but doesn't react. Another mnemonic used for the Argyll-Robertson Pupil (ARP) is Accommodation Reflex Present (ARP) but Pupillary Reflex Absent (PRA)

Features


small, irregular pupils


no response to light but there is a response to accommodate



Causes


diabetes mellitus


syphilis

Causes of mydriasis (large pupil)

third nerve palsy


Holmes-Adie pupil


traumatic iridoplegia


phaeochromocytoma


congenital

Relative afferent pupillary defect aka

Also known as the Marcus-Gunn pupil, a relative afferent pupillary defect is found by the swinging light test



It is caused by a lesion anterior to the optic chiasm i.e. optic nerve or retina

Relative afferent pupillary defect causes

retina: detachment



optic nerve: optic neuritis e.g. multiple sclerosis

Pathway of pupillary light reflex

afferent: retina optic nerve lateral geniculate body midbrain



efferent: Edinger-Westphal nucleus (midbrain) oculomotor nerve

A 74-year-old man presents with a severe throbbing headache on the right side of his head. He has now had this pain for around 6-7 days but reports no obvious trigger. There have been no visual disturbances or episodes of limb weakness. Neurological examination is unremarkable. The right side of his head is tender to touch but he cannot remember falling. Given the likely diagnosis what is the most important initial step?

Give high-dose oral prednisolone




Dx temporal arteritis

Each one of the following is a cause of a mydriatic pupil, except:

Argyll-Robertson pupil

Argyll-Robertson pupil is one of the classic pupillary syndrome. It is sometimes seen in neurosyphilis and is often said to be the prostitute's pupil - accommodates but doesn't react. Another mnemonic used for the Argyll-Robertson Pupil (ARP) is Accommodation Reflex Present (ARP) but Pupillary Reflex Absent (PRA)

Features


small, irregular pupils


no response to light but there is a response to accommodate



Causes


diabetes mellitus


syphilis

Causes of mydriasis (large pupil)

third nerve palsy


Holmes-Adie pupil


traumatic iridoplegia


phaeochromocytoma


congenital

Drug causes of mydriasis

topical mydriatics: tropicamide, atropine



sympathomimetic drugs: amphetamines, cocaine



anticholinergic drugs: tricyclic antidepressants

Which one of the following is associated with heterochromia in congenital disease?

Horner's syndrome

A 45-year-old man presents with a two week history of a painless lump in his left lower eyelid. A small lump is noted on examination which is more obvious when the eyelid is everted. There is no erythema or discharge. A diagnosis of a meibomian cyst is suspected. What is the most appropriate management?

Advise warm compresses + review in one month

A 54-year-old man with type 2 diabetes mellitus is found on annual review to have new vessel formation at the optic disc. Visual acuity in both eyes is not affected (6/9). Blood pressure is155/84 mmHg.



HbA1c 8.4%



What is the most important intervention to preserve vision in this patient?

Laser therapy

A 54-year-old man with type 2 diabetes mellitus is found on annual review to have new vessel formation at the optic disc. Visual acuity in both eyes is not affected (6/9). Blood pressure is155/84 mmHg.



HbA1c 8.4%



What is the most important intervention to preserve vision in this patient?

Laser therapy






This patient has proliferative diabetic retinopathy and urgent referral to an ophthalmologist for panretinal photocoagulation is indicated. Good glycaemic control is obviously beneficial in the long-term but this patient needs intervention quickly to preserve his vision.

This man presents with unilateral visual loss. On examination he has a relative afferent pupillary defect. Fundoscopy shows the following:



What is the most likely diagnosis?

Central retinal artery occlusion

This man presents with unilateral visual loss. On examination he has a relative afferent pupillary defect. Fundoscopy shows the following:



What is the most likely diagnosis?

Central retinal artery occlusion





The pale retina is the most obvious sign in this slide.

Which one of the following best describes the action of latanoprost in the management of primary open-angle glaucoma?

Increases uveoscleral outflow

Which one of the following is least associated with the development of optic atrophy?

Ataxic telangiectasia

This man presents with unilateral visual loss. On examination he has a relative afferent pupillary defect. Fundoscopy shows the following:



What is the most likely diagnosis?

Central retinal artery occlusion





The pale retina is the most obvious sign in this slide.

Which one of the following best describes the action of latanoprost in the management of primary open-angle glaucoma?

Increases uveoscleral outflow

Which one of the following is least associated with the development of optic atrophy?

Ataxic telangiectasia

Optic atrophy is seen as pale, well demarcated disc on fundoscopy. It is usually bilateral and causes a gradual loss of vision*.



Causes may be acquired or congenital

True

This man presents with unilateral visual loss. On examination he has a relative afferent pupillary defect. Fundoscopy shows the following:



What is the most likely diagnosis?

Central retinal artery occlusion





The pale retina is the most obvious sign in this slide.

Which one of the following best describes the action of latanoprost in the management of primary open-angle glaucoma?

Increases uveoscleral outflow

Which one of the following is least associated with the development of optic atrophy?

Ataxic telangiectasia

Optic atrophy is seen as pale, well demarcated disc on fundoscopy. It is usually bilateral and causes a gradual loss of vision*.



Causes may be acquired or congenital

True

Optic atrophy is seen as pale, well demarcated disc on fundoscopy. It is usually bilateral and causes a gradual loss of vision*. Causes may be acquired or congenital

Acquired causes


multiple sclerosis


papilloedema (longstanding)


raised intraocular pressure (e.g. glaucoma, tumour)


retinal damage (e.g. choroiditis, retinitis pigmentosa)


ischaemia


toxins: tobacco amblyopia, quinine, methanol, arsenic, lead


nutritional: vitamin B1, B2, B6 and B12 deficiency




Congenital causes


Friedreich's ataxia


mitochondrial disorders e.g. Leber's optic atrophy


DIDMOAD - the association of cranial Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness (also known as Wolfram's syndrome)



*strictly speaking optic atrophy is a descriptive term, it is the optic neuropathy that results in visual loss

A 61-year-old woman presents with bilateral tinnitus. She reports no change in her hearing or other ear-related symptoms. Ear and cranial nerve examination is unremarkable. Which medication is she most likely to have recently started?

Quinine

A 71-year-old man presents with two year history of intermittent problems with swallowing. His wife has also noticed he has halitosis and is coughing at night. He has a past medical history of type 2 diabetes mellitus but states he is otherwise well. Of note his weight is stable and he has a good appetite. Clinical examination is unremarkable. What is the most likely diagnosis?

Pharyngeal pouch

A 61-year-old woman with a history of cardiac problems develops hearing loss after a prolonged admission in hospital. Drug toxicity is suspected.

The correct answer is Furosemide induced

A 71-year-old man presents with two year history of intermittent problems with swallowing. His wife has also noticed he has halitosis and is coughing at night. He has a past medical history of type 2 diabetes mellitus but states he is otherwise well. Of note his weight is stable and he has a good appetite. Clinical examination is unremarkable. What is the most likely diagnosis?

Pharyngeal pouch

A 61-year-old woman with a history of cardiac problems develops hearing loss after a prolonged admission in hospital. Drug toxicity is suspected.

The correct answer is Furosemide induced

A 37-year-old cello player complains of a three month history of vertigo and hearing loss on the left side. On examination he has an absent corneal reflex on the left eye.

Acoustic neuroma

is diagnosed with Bell's palsy. What is the current evidenced base approach to the management of this condition?

Prednisolone

A 42-year-old man with a 3 month history of chronic cough presents with a persistent headache

Sinusitis



This patient has chronic sinusitis. The cough is secondary to a post-nasal drip

does optic neuritis cause SUDDEN PAINLESS LOSS OF VISION

NO NO

what is Ischaemic optic neuropathy

ischemia to the optic nerve causing damage due to either:




- arteritis e.g. GCA aka temporal arteritis or


- atherosclerosis in hypertensive, diabetic older patient