Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
50 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
List the gastric antisecretories
|
Famotidine
Lansoprazole Omeprazole Pantoprazole Sodium Esomeprazole Magnesium Ranitidine HCL |
|
|
|
Which antisecretories are generic?
|
Pantoprazole
Ranitidine Omeprazole Famotidine |
|
|
|
Brand name Famotidine?
|
Pepcid
|
Famous Pepsi kid (10 yo)
|
|
|
Indications for Famotidine?
|
Tx active duodenal ulcer (short term)
Tx benign gastric ulcers Tx pathological hypersecretory conditions (including severe Zollinger-Ellison Syndrome) Tx GERD (gastroesophageal reflux disease) Simpler: gastric, duodenal, Z-E, GERD Simpler: Ranitidine - errosive esophagitis |
Pepsi kid only did 4 things, he's just a kid
|
|
|
MoA for Famotidine?
|
Histamine H2 Rx blocker
Decs acid conc and volume |
|
|
|
DIs for Famotidine?
|
Decs warfarin clearance
|
He was fired at 10 yo for war-like tantrums.
|
|
|
Contras for Famotidine?
|
Caution with:
Renal impairment Pregnancy(cat B) and nursing When CrCl < 10ml/min dec dose to 20mg |
His mother regret giving birth and even nursing him, due to his war-like tantrums.
He tried to find work again at age 20, telling everyone he was a famous child actor. |
|
|
AEs for Famotidine?
|
Constipation
Headache Injection site irritation Dizzy Diarrhea |
He tells everyone "But I was a CHILD actor!!!", but he was just a child brat.
|
|
|
PxCx for Famotidine?
|
Shake well
Discard after 30 days |
His mom use to Shake him Well to stop his tantrums, and threatened to Discard him after 30 days. She went to a therapist who counseled her not to do this.
|
|
|
Brand name Ranitidine HCL?
|
Zantac
|
Zantac is a child running from a hungry blob. The blob has foam around its mouth, with syrup snot coming out of its nose, frozen to its face.
|
|
|
Indications for Ranitidine?
|
Tx duodenal and gastric ulcers
Tx GERD Tx pathological hypersecretory conditions (including Zollinger-Ellison Syndrome) Tx errosive esophagitis Simpler: All - helicobacter pylori Simpler: Famotidine + errosive esophagitis |
Zantac runs from the blob screaming and screaming so loud that his esophogus is erroding. Thats the only difference between him and that famous child actor. They both only do 4 things, but Zantac screams more and has that sore throat/esophagus.
|
|
|
MoA for Ranitidine?
|
Histamine H2 Rx blocker
|
|
|
|
DIs for Ranitidine?
|
Decs warfarin and lidocaine clearance
May inc absorption of triazolam May dec metab of nifedipine and TCA (tricyclic antidepressants) |
As Zantac runs through a field, he throws 3/tri lambs at the blob to quench its hunger. The blob absorbs them quickly, it like lamb, but it keeps on coming. So Zantac throws knives/knifedipine and a tricycle/TCA at it, but the blob doesnt like these and has trouble digesting/metabolizing them. Zantac is at war with the blob, just like the famous pepsi kid was with his mom and directors, but Zantac req's lidocaine for his sore throat.
|
|
|
Contras for Ranitidine?
|
Caution with:
Impaired renal or hepatic AE: Possible (reversible) hepatitis Pregnancy and nursing Efferdose tabs contain phenylalanine(so contra'd with phenylketonurics) |
Zantac doesnt just have kidney problems (like the famous kid), but also liver problems.
At the end of the movie Zantac throws a handgrenade at the blob and we think this will be a happy ending type of movie, but the blob spits out the grenade before it does any damage to its liver, reversing the damage. The last scene we see is the blob with something stuck between its teeth... |
|
|
AEs for Ranitidine?
|
Constipation
Headache AB PAIN Nausea Dizzy (note: not diarrhea because constipation is the opposite) |
...we see a Childs HAND!
Poor Zantac, so yummy. |
|
|
PxCx for Ranitidine?
|
Dont freeze syrup
Can take with food or milk if GI upset Dissolve effervescent tabs prior to ingestion Complete full course of therapy |
The blob has an upset stomach after eating yummy kids. He goes to a dietary counselor and they decide on a full course of therapy where the blob only eats regular food and milk. Dont forget the frozen snot and effervescent foam around his mouth! The counselor notices this and tells the blob to clean his face and learn some damn hygene.
|
|
|
Brand name Lansoprazole?
|
Prevacid
|
Lance armstrong was the PREVious winner of the Tour de France, so now he just does chessy commercials cause he's an attention whore.
|
|
|
Indications for Lansoprazole?
|
Tx gastric ulcers (short term)
Tx active duodenal ulcer (short term) Tx duodenal ulcers associated with Helicobacter pylori Tx pathological hypersecretory conditions(including Zollinger-Ellison Syndrome) Tx errosive esophagitis (short term) Tx GERD (gastroesophageal reflux disease) |
Lance is a champ though, he can do everything, all 6 things (that are seen with gastric antisecs).
|
|
|
MoA for Lansoprazole?
|
PPI (proton pump inhibitor):
Inhibits H+/K+ ATPase (proton pump) in gastric parietal cells |
So the cheesy commercial starts with the camera panning in to Lance pumping up his bicycle with a proton pump (imagery: has some cool skull stickers and the name "The Inhibitor").
|
|
|
DIs for Lansoprazole?
|
Sucralfate (take lansoprazole 30 mins prior to sucralfate)
Drugs where gastric pH determines BA (eg ketoconazole, ampicillin esters, iron salts, digoxin) Theophylline (may req titration) |
Next scene: Lance on his bike ("KAID" is the brand on the crosspiece).
The bike has a grannybasket in front of the handlebars with a midget sitting in it. The midget has a big whole where his stomach should be, and he's always saying how hungry he is. The midget also has two IV lines (with inline filters) coming out of his arms, tieing him to the basket so he cant get away (Lance is a bit sadistic). The basket is filled with delayed release granules and a partly filled (30ml) glass of water. Lance says he can put some granules in the water and drink it if he wants, but thats all. Theo from the Cosby show is on the banana seat behind Lance laughing at the midgets plight, throwing cubes of sucrose at the midget, "You hungry? Too bad this is your fate for 30 minutes while we film". |
|
|
Contras for Lansoprazole?
|
None really
FYI: Pregnancy cat B |
The camera zooms away from the midget and Theo and onto Lances face as he says his lines: "Hi I'm Lance armstrong, and I'm a bad mofo, no one can contraindicate me, the only thing I worry about is getting women pregnant cause everyone wants to sleep with me".
|
|
|
AEs for Lansoprazole?
|
Headache
Ab pain Nausea Diarrhea |
The camera pans to the crowds lining the street as Lance bicycles into the sunset, all you see is big HANDS waving at him.
|
|
|
PxCx for Lansoprazole?
|
Take on empty stomach
Can mix delayed release granules in 30ml of water and drink immediately IV must use inline filter |
|
|
|
Brand name Omeprazole?
|
Prilosec
|
|
|
|
Indications for Omeprazole?
|
Tx active duodenal ulcer (short term)
Adjunct for tx of Helicobacter pylori infection(assoc w/ duodenal usually) Tx errosive esophagitis (short term) Tx pathological hypersecretory conditions(including Zollinger-Ellison Syndrome) Tx GERD Simpler: All - gastric |
|
|
|
MoA for Omeprazole?
|
PPI (proton pump inhibitor)
|
|
|
|
DIs for Omeprazole?
|
Inhibits metab of cilostazole
Inhibits conversion of clopidogrel to its active metabolite Incs plasma levels of diazepam, phenytoin, and warfarin (inhibits their oxidative metabolism) Cyp450 interactions with cyclosporine, disulfiram, benzodiazepines(eg diazepam) Drugs where gastric pH determines BA (eg ketoconazole, ampicillin esters, iron salts, digoxin, cyanocobalamin) Voriconazole may inc plasma levels of omeprazole |
|
|
|
Contras for Omeprazole?
|
None really
AE: Animal studies show risk of gastric carcinoid tumors with long term use and very high dosage |
|
|
|
AEs for Omeprazole?
|
Omeprazole Rare:
Back pain Dizzy Rash Cough Constipation |
|
|
|
PxCx for Omeprazole?
|
Take omeprazole 30 mins prior to eating
|
|
|
|
Brand name Esomeprazole Magnesium?
|
Nexium
|
|
|
|
Indications for Esomeprazole?
|
Tx errosive esophagitis (short term)
Tx GERD Adjunct for tx of Helicobacter pylori infection(assoc w/ duodenal ulcers) Tx pathological hypersecretory conditions(including Zollinger-Ellison Syndrome) Gastric ulcers assoc with continuous NSAID therapy Simpler: Omeprazole - general duodenal ulcer + gastric/NSAID ulcer |
|
|
|
MoA for Esomeprazole?
|
PPI (proton pump inhibitor)
|
|
|
|
DIs for Esomeprazole?
|
Esomeprazole inhibits metab of cilostazole
Inhibits conversion of clopidogrel to its active metabolite Esomeprazole Incs plasma levels of diazepam Drugs where gastric pH determines BA (eg ketoconazole, ampicillin esters, iron salts, digoxin, cyanocobalamin) Voriconazole may inc plasma levels of esomeprazole Esomeprazole may dec plasma levels of atazanavir |
|
|
|
Contras for Esomeprazole?
|
Note: BOTH of these are AEs not contras
Animal studies show risk of gastric carcinoid tumors w/ long term use & very high dosage. Rare: Can cause severe dermatologic rxns (including toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme). |
|
|
|
AEs for Esomeprazole?
|
Headache
Ab pain Nausea Diarrhea Constipation Flatulence Dry mouth "Fart to the HAND or it goes in your Dry mouth" |
|
|
|
PxCx for Esomeprazole?
|
Take at least 60 mins prior to eating
Mix granules with one tablespoon (15ml) of water for 2-3 mins, then drink within 30 mins |
|
|
|
Brand name Pantoprazole Sodium?
|
Protonix
|
|
|
|
Indications for Pantoprazole?
|
Tx errosive esophagitis (short term)
Tx pathological hypersecretory conditions(including Zollinger-Ellison Syndrome) Tx GERD Simpler: No gastric or duodenal |
|
|
|
MoA for Pantoprazole?
|
PPI (proton pump inhibitor)
|
|
|
|
DIs for Pantoprazole?
|
Drugs where gastric pH determines BA
(eg ketoconazole, ampicillin esters, iron salts) |
|
|
|
Contras for Pantoprazole?
|
Severe hepatic impairment
|
|
|
|
AEs for Pantoprazole?
|
Rare:
Diarrhea Rash Headache Flatulence |
|
|
|
PxCx for Pantoprazole?
|
nothing special
|
|
|
|
Dosage forms/strs for Famotidine?
|
Tabs 20/40mg
ODT 20/40mg Powder for oral susp 40mg/5ml Premixed injection 20mg/50ml Injection 10mg/ml OTC (non-rx) 10/20mg |
|
|
|
Dosage forms/strs for Lansoprazole?
|
Caps 15/30mg
ODT 15/30mg Delayed release granule for oral susp 15/30mg Powder for injection 20mg/vial |
|
|
|
Dosage forms/strs for Omeprazole?
|
Sustained release caps 10/20/40mg
OTC (non-rx) 20mg |
|
|
|
Dosage forms/strs for Pantoprazole?
|
Delayed release tabs 20/40mg
Granules for oral susp 40mg/packet Powder for injection 40mg/vial |
|
|
|
Dosage forms/strs for Esomeprazole?
|
Delayed release caps 20/40mg
Granules for oral susp 10/20/40mg Powder for injection 20/40mg |
|
|
|
Dosage forms/strs for Ranitidine?
|
Tabs 150/300mg
EFFERdose tabs 25/150mg Syrup 15mg/ml Injection 25mg/ml OTC (non-rx) 75/150mg |
|
