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35 Cards in this Set
- Front
- Back
What am I:
biological factors which act like hormones, have a brief duration, act near the site of synthesis, and are not blood borne |
autacoids
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Histamine and serotonin fall under what class of autacoids?
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amine autacoids
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prostaglandins, thromboxanes, and leukotriens fall under what class of autacoids?
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eicosanoids
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kinins, renin, and angiotensins fall under what class of autacoids?
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peptide autacoids
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What am I:
bio-amine derived from the decarboxylation of aminoacid histidine |
histamine
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This type of histamine receptor is located on smooth muscle, endothelium, and sensory nerves
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H1
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This type of histamine receptor causes:
bronchoconstriction by smooth muscle contraction vasodilation by nitric oxide release pain and itching via neuronal stimulation |
H1
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This type of histamine receptor is located on the gastric mucosa
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H2
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What generation antihistamine am I:
small, lipophilic molecules that can cross the BBB not highly selective to histamine receptors - also blocks cholinergic, adrenergic, and serotonin receptors |
first generation
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sedation, dry mouth, urinary retention, and tachcardia are adverse effects of 1st generation antihistamines due to which receptor blockade?
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cholinergic
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postural hypotension is an adverse effect of first generation antihistamine due to what receptor blockade?
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adregergic
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increased appetite is an adverse effect of first generation antihistamine due t owhat receptor blockade?
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serotonin
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Which antihistamines have marked sedation?
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dimenhydrinate
diphenhydramine hydroxyzine promethazine |
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Which antihistamines are also used for motion sickness?
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cyclizine
meclizine dimenhydrinate diphenhydramine |
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What are the clincal uses of first generation antihistamines?
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symptomatic relief of seasonal allergic rhinitis and urticaria where histamine is the primary mediator
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Which antihistamine also has antiemetic activity?
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promethazine
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what generation antihistamine am I:
Does not readily cross BBB more selective for H1 receptors |
second generation
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These drugs are metabolite derivatives or active enantiomers of existing drugs. They are safer, faster acting, and/or more potent than 2nd generation antihistamines
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fexofenadine
desloratadine levoceterizine |
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What receptor am I:
monoamine neurotransmitter synthesized from the amino acid tryptophan |
serotonin
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Drugs that end in ______ are selective serotonin agonist.
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triptan
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What are selective serotonin agonists indicated for?
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abortive therapy in the treatment of migraine and cluster headaches
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What class of drug am I:
selective agonist for serotonin in the cranial arteries. cause vasoconstriction and reduce release of pro-inflammatory neuropeptides |
selective serotonin agonist
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concurrent use of triptans with these drugs can predispose patients to serotonin syndrome
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MAOI
SSRI SNRA |
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What is contraindicated in triptans?
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patients with CAD
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What is the common adverse effect of triptans
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paresthesia
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ergotamine and dihydroergotamine have this selectivity
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vasoselectivity
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ergonovine has this selectivity
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uteroselectivity
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lysergic acid and diethyamide has this selectivity
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CNS selectivity
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which serotonin receptors are triptans selective for?
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5HT-1B
5HT-1D |
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Which serotonin receptors are ergotamine and dihydroergotamine selective for?
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5HT-1A
5HT-1D |
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Which serotonin receptor is ergonovine selective for?
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5HT-1A
5HT-1D |
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Which receptor are lysergic acid and diethyamide selective for?
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DA
5HT-2 |
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What substance facilitates the oral bioavailability of ergotamine?
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caffeine
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What drug am I:
semisynthetic ergot alkaloid derivative dopamine agonist activates postsynaptic dopamine recetpros in tuberinfundibular and nigrostriatal pathways |
bromocriptine
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What is bromocriptine indicated for?
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hyperprolactinemia associated with amenorrhea with or without galactorrhea, infertilibity or hypogonadism
prolactin-secreting adenomas acromegaly parkinson's disease |