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36 Cards in this Set
- Front
- Back
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a patient has been overdosed with an irreversible AChE? how do you help them
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1. maintain vital signs
2. remove patient from exposure 3. atropine 4. 2-PAM you can prolong the time to get help by giving a reversible AChE to block the binding site so the irreversible AChE wont bind |
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a patient has a hard trauma with consequent damage to their parasympathetic sacral nerve? what drugs can you use to substitute?
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cholinergic agonist
example: bethanechol |
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what is the mechanism for succinylcholine
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neuromuscular blocking agent
1. depolarizing the NMJ 2. desensitize the nAChR because AChE can't break it down |
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when compared to rocuronium, tubocurarine...
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what can be used to dephosphorylate AChE
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PRALIDOXIME (2-PAM)
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what is the mechanism for pilocarpine
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activate parasympathetic organs secondary to stimulating ganglionic receptors
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anticholinergic (atropine) should NOT be used for a gastric ulcer because
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it is not selective for decreasing stomach acid production and it inhibits gastric acid being emptied from the stomach
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reserpine acts by...
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depleting the reservoirs of norepinephrine from the nerve terminal
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cholinergic agents will have effects that overlap with
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anticholinesterase drugs
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propranolol is CONTRAINDICATED in patients with
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NON SELECTIVE BETA BLOCKER
1. hyperthyroidism 2. congestive heart failure 3. asthma 4. diabetes |
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mechanism by which phenylephrine treats paroxysmal atrial tachycardia is...
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phenylphrine will increase blood pressure through stimulation of alpha 1 receptors, which leads to a reflex bradycardia
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muscarine stimulates what receptor sites?
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parasympathetic organs and tissues
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what alpha antagonist binds IRREVERSIBLY to alpha 1 receptors
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PHENOXYBENZAMINE
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what is an anticipated effect of a beta 1 blocker (atenolol)
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basically beta blocker effects
1. decreased heart rate 2. decreased renin release 3. decreased blood pressure 4. decreased contractility |
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beta receptors would be expected to down regulate with the chronic administration of what
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BETA AGONIST like albuterol
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what are the beta 1 blockers
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A.N.A.M.E
1. acebutolol 2. nebivolol 3. atenolol 4. metoprolol 5. esmolol |
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what are the non selective beta blockers
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1. propranolol
2. penbutolol 3. pindolol 4. carvedilol 5. labetalol 6. nadolol 7. timolol |
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what is a CONTRAINDICATION of albuterol?
what other drugs have the same contraindications |
1. hypertension
2. coronary artery disease 3. congestive heart failure 4. diabetes TRAM: terbutaline, ritodrine, albuterol, metaproterenol |
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what is a beta 1 agonist
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dobutamine
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what class of drug is isoproterenol
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non selective beta agonist
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the primary variable in the cardiovascular system that is controlled by the ANS is...
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mean arterial pressure
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what is norepinephrine selective for
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alpha agonist
beta 1 agonist |
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what is an alpha 1 agonist that can be administered systemically as a pressor agent
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phenylephrine
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what are the indirect acting sympathomimetics
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1. amphetamine
2. methamphetamine 3. methylphenidate 4. pemoline |
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what is the mechanism for phenylpropanolamine
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induces catecholamine release
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what are the cholinergic agonist?
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esters:
1. acetylcholine 2. methacholine 3. carbachol 4. bethanechol alkaloids 1. muscarine 2. pilocarpine 3. nicotine |
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what is the selectivity for phenylephrine and methoxamine
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alpha 1 selective agonist
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what is the selectivity for clonidine
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alpha 2 selective agonist
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what is the selectivity for norephinephrine
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non selective alpha agonist
beta 1 selective agonist |
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what is the selectivity for epinephrine
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non selective alpha agonist
non selective beta agonist |
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what is the selectivity for dobutamine
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beta 1 selective agonist
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what is the selectivity for isoproterenol
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non selective beta agonist
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what is TRAM?
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beta 2 selective agonist
terbutaline metaproterenol albuterol ritodine |
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what is phenotolamine
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non selective alpha antagonist
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what is phenoxybenzamine
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alpha 1 antagonist
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what drugs are alpha 1 selective antagonist
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1. tamsulosin
2. prazosin 3. terazosin 4. doxazosin phenoxybenzamine not as selective as above |
