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43 Cards in this Set
- Front
- Back
NSAIDS and acetaminophen action |
inhibit COX (cyclooxygenase) |
|
action of COX |
converts arachidonic acid into prostaglandins (PAIN, INFLAMMATION) |
|
first generation NSAIDS inhibit |
COX1 and COX2 (unselectively) |
|
second generation NSAIDS inhibit |
COX 2 selectively |
|
3 SE of first generation NSAIDS |
ulcers renal bleeding |
|
1 SE of 2nd gen NSAIDS |
renal |
|
prototype for first gen NSAID |
aspirin |
|
four benefits of aspirin |
inflammation pain fever MI/stroke (antiplatelet) |
|
three benefits of of COX 2 inhibition |
inflammation, pain, fever |
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1 benefit of COX 1 inhibition |
antiplatelet (MI / stroke) |
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_______ generation NSAIDs aka ___________'s inhibition of COX is irreversible |
1s generation... aka aspirin |
|
single dose of aspirin has antiplatelet effect for life of platelet which is ________ |
8 days |
|
take aspirin ___________ before other NSAIDS |
2 hours before |
|
ibuprofren is___________ |
1st generation non aspirin NSAID |
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because of renal impairment properties, aspirin not good for those with |
at risk for CHF (hypovolemia, hypertension, CHF) |
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aspirin and NSAIDs should be avoided in children with influeza due to potential ________ syndrome |
reyes syndrome |
|
treat allergic reactions with |
epinephrine |
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three differences between aspirin and non aspirin 1st generation NSAIDS |
non aspirin 1st generation NSAIDS: reversible antiplatelet not for MI can actually cause MI/stroke |
|
aspirin ____________ for labor and delivery |
not good |
|
seond gen NSAIDS also known as |
coxibs |
|
coxibs only inhibit COX |
COX 2 |
|
main differences between coxib and 1st generation NSAIDS |
less ulcers no antiplatelet |
|
coxibs and MI/stroke? |
yes, they also cause it like non aspirion 1s gen NSAIDS |
|
name one coxib |
celebrex |
|
acetaminophen ihbitis prostaglandins in _______ only |
CNS |
|
two benefits of acetaminophen |
fever pain |
|
one risk of acetaminphen |
liver damage |
|
acetaminophen ihibits metabolism of this drug |
warfarin |
|
watch out for this with acetaminphen |
rash |
|
antidote to acetominophen |
acetylcysteine |
|
other routes NSAIDs (topical etc) |
wnd with -olacs
|
|
discard asprin that smells like |
vinegar |
|
NSAIDS with least antiplatelet properties |
-cylates |
|
tinnitus |
ringing in ear |
|
celecoxib (2nd gen NSAID) not good for those with this allergy |
sulfa allergy |
|
NSAIDS and aspirin may interact with this primary prevention measure |
vaccines |
|
NSAIDS cause renal issues with these two heart meds |
ACE and ARBS (prils, sartans) |
|
acetaminophen caution with |
alcohol |
|
alcoholics should take no more than _______ mg of acetaminophen per day |
2000mg |
|
Dysmenorrhea means |
painful menstrual cramps |
|
Hematemesis means |
vomiting blood |
|
which NSAID should you avoid after heart bypass surgery? |
second gen NSAID, celebrex |
|
aspirin poisonoing can have what effect on temperature? |
fever, hyperthermia |