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21 Cards in this Set

  • Front
  • Back
List the two first generation H1 antagonists.
Diphenhydramine
Chlorpheniramine
List the three second generation H1 antagonists
Fexofenadine
Loratadine
Citrizone
What are the contraindications of Fexofenadine?
Glaucoma
Urinary Retention
MAOI's
What are the contraindications of Loratadine?
Pregnancy
Breast Feeding
What are two general contraindications for anti-histamines?
COPD
Asthma
What is the elimination for the H1 antagonists? Approximately how long are the half lives for each generation?
All are hepatic

1st generation: 4-6 hrs
2nd generation: 12-24 hrs
What are the side effects of H1 blockers?
Anorexia
Nausea/Vomiting
Blood dyscarias
What is the advantage of the second generation H1 antagonists?
They don not cross the BBB and therefore done cause the same fatigue.
What is Doxepin
A tricyclic antidepressant. It has very strong H1 blocking effects too.
What are the indications for the H2 antagonists?
Ulcers
GERD
Prevention of esophageal bleeding
List 4 H2 antagonists.
Cimetidine
Ranitidine
Famotidine
Nizatidine
What are contraindications of H2 antagonists?
Not much really.

Gynecomastia in a small number of men.

Reduce doses with liver/renal patients
What are some of the effects of histamine?
Dilitation of the afferent arterioles
Hypotension
Increased intercellular space

Gastric Secretion

Bronchoconstriction
List 5 PPI's
Omeprazole
Lansoprazole
Pantoprazole
Rabeprazole
Esomepraxole
What are the indications for PPI's
Gastric Ulcers
GERD (secondary to H2 blockers)
Treatment of H. Pylori
What are the contraindications for PPI's
H2 antagonists
Benzodiazpines
Warfarin
Phenytoin
What is the MOA of PPI's
Irreversibly inhibit H/K ATPases. The drugs are prodrugs activated in an acidic environment
What are the side effects of PPI's?
Myalgia
Diarrhea, headache, constipation
What are the indications of sucralate?
Duodinal ulcers, it is a mucosal coating agent.
What are the contraindications of sucralfate?
H2 blockers
Floroquiniliones
Digoxin
Grapefruit (absorbs Al in compound)
What is the treatment of H. Pylori ulcers?
2 of 3 Antibiotics: Metronidazole, Claritromicin, Amoxicillin (1 week)
-or-
PPI + 1 antibiotic (2 weeks)