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15 Cards in this Set
- Front
- Back
1/2 life?
|
0.693xVd
/ Cl |
|
Vd (volume of distribution)?
**often expressed as L/Kg (calculate w/ body weight) |
dose x F (bioavailability)
/ Initial concentration |
|
Clearance?
|
rate of elimination
/ Drug concentration |
|
Cpss (steady state drug concentration)
|
Dose x F
/ Interval x Cl |
|
Initial concentration achieved
|
Dose x F
/ Vd **derived from above equation solving volume distribution |
|
What happens if FIRST PASS EFFECT impacted?
|
F increases and clearance decreases
-->serum concentration (Cssp) increases x 4 |
|
weak acids bind to ?
|
albumin
|
|
weak bases bind to?
|
alpha-1-acid glycoproteins
|
|
Phase I rxns
|
dealkylation
hydroxylation oxidation reduction hydrolysis |
|
phase II rxns
|
addition of...
-glucuronic acid -sulfate -glutathione -aa -acetate |
|
catalyze most oxidation, reduction, and hydrolysis reactions
|
microsomal
|
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what kind of conjugation does microsomal do?
|
glucuronide only
|
|
enzyme induction w/ microsomal or non-microsomal?
|
micrsomal
|
|
Nonmicrocomal --> what kind of conjugations?
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all but GLUCORONIDE
|
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Proximal tubule or distal tubule --> specific transport systems?
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Proximal --> nonspecific
Distal-->specific |