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56 Cards in this Set
- Front
- Back
_____________ is a chronic relapsing skin disease that can occur at any age. It is characterized by sharply demarcated lesions with clear cut borders, noncoherent silvery scales and a positive Auspitz sign.
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Psoriasis
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A positive sign is when:
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A blood droplet forms when you scratch off a scale.
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Psoriasis has a preference for _____________surfaces and _____________. They also tend to be _____________ and _____________.
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Extensor, buttocks, bilateral, symmetrical
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_____________ is the sudden appearance of numerous monomorphic psoriasis papules on the trunk and is often triggered by _____________ infection, particularly in adolescents and young adults without history of psoriasis.
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Guttate psoriasis, streptococcal.
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Guttate means _____________.
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Drop like
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Larger, chronic psoriasis plaques respond well to _____________therapy.
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UV light
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Painless separation of the nail from the nail bed that is associated with psoriasis.
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Onycholysis
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_____________ is the most characteristic sign of psoriasis on the nail plate.
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PItting
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Psoriatic lesions may develop after skin trauma, an effect called the____________.
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Koebner phenomenon
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_____________psoriasis is the least common form, but can be severe and require hospitalization.
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Erythrodermic
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Eryrthrodermic psoriasis is characterized by extensive _____________ and skin _____________ with itching and pain that can also affect _____________ control and _____________.
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Erythema, exfoliation, body temperature, heart rate
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__ to __% of psoriasis patients develop psoriatic arthritis, which is considered to be one of the sero-negative spondyloarthropathies. This anomaly is usually preceded by _____________ of psoriasis.
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5-20%, many years
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The skin changes in psoriasis stem from the increased rate of proliferation and shedding of _____________
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Keratinocytes
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Psoriasis is a _____________ mediated process in which CD4+ cells stimulate _____________ proliferation.
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T-Cell, keratinocyte
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_____________ and _____________ of psoriasis are typical over a lifetime.
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Exacerbations and remissions
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Topical treatments for psoriasis include _____________, creams, _____________, _____________ and _____________ light.
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Tar, steroids, cacipotriene, ultraviolet
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PUVA is _____________ + _____________, and is a treatment for _____________.
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Psoralens + UV, psoriasis
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Oral drugs for psoriasis include _____________, _____________, _____________ and _____________
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Retinoids, methotrexate, cyclosporin, steroids
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An uncommon, inflammatory papulosquamous disorder of unknown etiology.
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Lichen planus
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_____________, _____________, _____________ and _____________ (especially the oral mucosa) may be affected by lichen planus.
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Skin, nails, hair, mucous membranes
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Itching involved with lichen planus is usually _____________, most often intermittent, and _____________
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Variable, insatiable
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Lichen planus can occur _____________ as generalized disease, and may be secondary to a _____________.
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Abruptly, drug.
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In rare cases, oral lichen planus may degenerate into _____________.
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Squamous cell carcinoma
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White, violaceous, hyperkeratotic plaque with a white, lacelike pattern on the surface is known as _____________ and is associated with _____________.
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Wickham striae, lichen planus
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In oral lichen planus, lacy white plaques called _____________ are present on the _____________, and are usually bilateral and _____________.
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Wickham's striae, buccal mucosa, symmetrical
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Lichen planus prefers the _____________ surfaces of the wrists, forearms, ankles, abdomen and sacrum.
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Flexor
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What are the five P's of lichen planus?
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Pruritic, planar, polygonal, purple (violaceous), papules/plaques
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Lichen planus is a _____________ disease that usually resolves within __ to __ months.
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Self limited, 8-12
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The first line of treatment for lichen planus is _____________.
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Topical steroids`
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This is a common, chronic inflammatory papulosquamous disease with unknown etiology. It is characterized by yellow, greasy and scaling papules with coalescing red patches and plaques.
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Seborrheic dermatitis
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Seborrheic dermatitis favors areas where the _____________ of _____________ is maximal, such as the scalp margins, central face and presternal areas.
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Concentration of sebaceous
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Characteristic locations of seborrheic dermatitis are the _____________, base of the _____________, _____________ folds and _____________ skin, and external _____________ canals.
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eyebrows, eyelashes, nasolabial, paranasal, ear
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Scale adherent to the eyelashes and lid margins with variable amounts of erythema is characteristic of _____________.
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Seborrheic dermatitis.
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Seborrheic dermatitis has been linked to _____________ yeast in adolescents and adults.
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Pityrosporum (Malassezia)
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Seborrhea in infants is usually a _____________ condition that rarely requires treatment. If it must be treated, it can be with _____________ and a soft _____________. Low strength _____________ may be needed for resistant cases
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Self-limiting, oil, brush, corticosteroid
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Infantile _____________ and _____________ often occur simultaneously, which can be confusing when deciding on a treatment.
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Seborrhea, atopic dermatitis
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A method of distinguishing between seborrheic dermatitis and psoriasis is that SD prefers _____________ surfaces while psoriasis prefers _____________ surfaces of the extremities.
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Flexor, extensor
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SD lacks the characteristic vivid red hue or _____________ scale of psoriasis, which is generally more _____________ or _____________ colored.
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micaceous, pink, salmon
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Seborrheic dermatitis is treated with topical _____________, antidandruff shampoo or soaps containing _____________ (ZNP), selenium sulfide, _____________, coal tar, salicylic acid and tea tree oils.
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antifungals, zinc pyrithione, ketoconoazole
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Poorly defined, erythematous patches, papules and plaques with or without a scale in which the skin appears edematous. Erosions are moist, crusted, linear or punctuate, resulting from scratching. Skin may be extremely _____________, _____________ and _____________.
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Acute atopic dermatitis, dry, cracked, scaly.
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Lichenification resulting from repeated rubbing or scratching; follicular lichenification (especially in darkly pigmented persons).
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Chronic atopic dermatitis.
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_____________ atopic dermatitis is characterized by _____________, which are painful, especially in flexures, on palms, fingers and soles.
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Chronic, fissures
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Thickening and hardening of the skin, often resulting from the irritation caused by repeated scratching of a pruritic lesion.
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Lichenification
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Atopic dermatitis usually begins in _____________, before the age of _____________ years.
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Infancy, 5
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Atopic dermatitis is characterized by _____________ skin and _____________; consequent rubbing leads to increased inflammation and _____________ and to further itching and scratching. This is known as the _____________ cycle.
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Dry, Pruritis, lichenification, itch-scratch
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Atopic dermatitis is believed to be the result of a _____________ dysfunction and _____________ reactivity.
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skin barrier, IgE
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Atopic dermatitis has a strong/weak genetic basis.
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Strong
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Atopic dermatitis can be exacerbated by _____________ disruption, which is a decrease of barrier function and increased transepidermal _____________. The patient must limit bathing and hand washing, as _____________ is an exacerbating factor.
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Skin barrier, water loss, dehydration
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_____________ and _____________ are two organisms that can exacerbate atopic dermatitis.
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S. aureus, group A strep
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Atopic dermatitis in children presents as papular, lichenified plaques, erosions and crusts on the _____________ and _____________ fossae, the _____________ and the _____________.
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Antecubital, popliteal, neck, face
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_____________ and _____________ are the most conspicuous symptoms of atopic dermatitis on adults.
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Lichenification and excoriations
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Management of atopic dermatitis include _____________ skin care with _____________ and topical _____________, _____________ therapy and _____________ as sedatives.
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Optimal, hydration, moisturizers, wet-wrap, antihistamines
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Pathogenesis of _____________ is activated CD4+ T cells that produce inflammatory cytokines, resulting in keratinocyte hyperproliferation.
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Psoriasis
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Pathogenesis of _____________ is activated CD8+ T cells that kill keratinocytes and release inflammatory cytokines.
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Lichen planus
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Pathogenesis of _____________ is immune/inflammatory response to Malassesia, resulting in complement activation.
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Seborrheic dermatitis
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Pathogenesis of _____________ is an impaired skin barrier; related to IgE mediated diseases.
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Atopic dermatitis
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