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34 Cards in this Set
- Front
- Back
4 causes of microcytic anemia
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TICS-Thalassemia,Iron-def,anemia of Chronic dz,and Sideroblastic anemia
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Elderly man with hypochromic, microcytic anemia is asymptomatic. Dx test?
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Fecal occult blood test and sigmoidoscopy; suspect colorectal cancer
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Precipitants of hemolytic crisis in pts with G6PD def
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Sulfonamides, anti-malarial drugs, fava beans
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Most common inherited cause of hypercoagulability
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Factor V Leidin mutation
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Most common inherited bleeding disorder
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von Willebrands dz
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Most common inherited hemolytic anemia
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Hereditary spherocytosis
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Dx test for hereditary spherocytosis
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osmotic fragility test
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Pure RBC aplasia
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Diamond blackfan anemia
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anemia a/w with absent radii and thumbs, diffuse hyperpigmentation, cafe au lait spots, microcephaly, and pancytopenia
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Fanconi's anemia
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Meds and viruses that lead to aplastic anemia
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Chloramphenicol, sulfonamide, radiation, HIV, chemo, hepatitis, parvovirus B19, EBV
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Distinguish polycythemia vera from secondary polycythemia
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Both have INC'd HCT and RBC mass, but PV should have nl O2 sat and low EPO levels
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TTP pentad
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FAT RN: Fever, anemia, thrombocytopenia, renal dysfx, neurologic abnl
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HUS triad
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Anemia, thrombocytopenia, ARF
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Tx for TTP
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Emergent large vol plasmapheresis, CSs, antiplt drugs. Plt transfusion is CI
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Tx for ITP in kids
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Usually resolves spontaneously, may require IVIG and/or CSs
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Which of the following are INC in DIC: fibrin split products, D-dimer,fibrinogen,plts,and hct
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Fibrin split products and D-dimer are elevated; plts, fibrinogen, and hct are DEC
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8 y/o boy with hemarthrosis and INC PTT with nl PT and BT. Dx? Tx?
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Hemophilia A or B; consider desmopressin (for hem A) or factor VIII or IX supplements
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14 y/o girl with prolonged bleeding after dental surgery and and with menses, nl PT, nl or INC PTT, INC BT. Dx? Tx?
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Von willebrand's dz, tx with desmopressin, FFP,or cryoprecipitate
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60 y/o black man with bone pain. What might work up for MM reveal?
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Monoclonal gammopathy, Bence jones proteinuria, and "punched-out" lesions on x-ray of skull and long bones
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Reed-sternberg cells
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Hogkin's lymphoma
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10 y/o boy with fever, wt loss, and night sweats. Exam shows anterior mediastinal mass. Suspected dx?
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NHL
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Microcytic anemia with DEC serum Fe, DEC TIBC, and NL or INC ferritn
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ACD
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Microcytic anemia with DEC serum Fe, DEC ferritin, and INC TIBC
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Fe Def anemia
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80 y/o man with fatigue, lymphadenopathy,splenomegaly,and isolated lymphocytosis. Dx?
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CLL
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Lymphoma equivalent of CLL
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Small lymphocytic lymphoma
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Late,life threatening complication of CML
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Blast crisis (fever, bone pain, splenomegaly, pancytopenia)
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Auer rods on blood smear
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AML
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AML subtype a/w DIC. Tx?
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M3. Retinoic acid
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Electrolyte changes in tumor lysis syndrome.
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DEC Ca, INC K, INC PO4, INC uric acid
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50 y/o man with early satiety, splenomegaly,and bleeding. Cytogenetics show t(9,22). Dx?
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CML
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Heinz bodies.
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Intracellular inclusions seen in thalassemia, G6PD def, post-splenectomy
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Virus a/w aplastic anemia in pts with sickle cell anemia
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parvovirus B19
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25 y/o black with sickle cell anemia has sudden onset of bone pain. Management of pain crisis?
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O2, analgesia,hydration,and, if severe, transfusion
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Significant cause of morbidity in thalessemia pts. Tx?
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Fe overload; use deferoxamine
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