Toxicology Crossword

Specific carbamate for which 2-PAM therapyis contraindicated:

Naphthalene causes this kind of damage to RBCs:

Stimulation of this by nicotine can causeself-decontamination:

IV ________ therapy is sometimesused to treat highly lipophilic toxins

Piscicide that targets cellular metabolism:

Rapid paralysis of insects by the action ofpyrethrins on neuronal sodium channels:

Acidificaton of the urine can __________ excretion of nicotine

Treats severe muscle tremors in pyrethrin toxicity:

The Half-life of ivermectin is ________ than 
that of amitraz

Specific antagonist for amitraz toxicity:

Dose repeatedly if a toxin is known to undergoenterohepatic recycling:

Where most ivermectin is excreted intact:

This happens to organochlorines in fat animals:

Protein responsible for keeping ivermectin outof the CNS:

Suspected to be part of D-limonene'smechanism of action:

Contraindicated if significant CNS depression orseizures present

Organophosphate bond to AChE, different fromcarbamates

Toxin with a very rapid onset that could be enhanced byconcurrent antacid therapy:

Onset and duration of carbamate toxicity isusually than organophosphate:

Naphthalene mothballs do it in salt water:

Used in treatment of bothorganophosphate and carbamate toxicity

Channels that organochlorines target

Species most sensitive to pyrethrins:

Inhibitory neurotransmitter that accounts forsome of the toxicity with ivermectin

CNS is a common presenting signof amitraz toxicity

Perhaps the most prominent sign with pyrethrintoxicity

Can occur during aggressivetreatment of pyrethrin toxicity and prolong clinical signs

Very high lipophilicity of DDT has led to this inthe food chain

Organochlorine toxicity usually causes
 __________ of the CNS

Clinically found in cats with naphthalenetoxicity:

Nicotine, organophosphates and carbamates allmimic exaggerated amounts of this neurotransmitter

Free hemoglobin poses a risk of damage to these:

These pyrethroids are more potent insecticidesbecause of their alpha-cyano group:

Can greatly enhance theabsorption of rotenone:

Increases the skin absorption of somepyrethroids (like fenvalerate):

A common feature of organochlorine toxicosis:

Pyrethrins and pyrethroids are relatively__________ in air and light

Rotenone metabolites in mammals are this,different from fish and insects

Presence of organochlorine residues in thistissue confirms exposure but not toxicity

With organophosphates this kind ofpolyneuropathy is sometimes seen

Flower extract that can be used as an insecticide:

Receptors first affected by acetylcholinesteraseinhibitors:

With nicotine toxicity a __________ urine pH will reduce excretion

D-limonene is frequently used in shampoos thatrepel or treat this parasite:

Fenthion is an example of anorganophosphate that requires this for toxicity

Dichlorvos is unique among OPs in that it can dothis in fat:

Late stages and ultimate death with OP and Carbamatetoxicity results from this occurring at nicotinic receptors

Toxic Epidermal Necrolysis has rarely beenreported with this product

If a cat presents with acute toxicity consistingof CNSdepression,hypotension and a wet oily spot on their back you maynot be surprised if the spotsmells like this

A RBC morphology thatindicates oxidative stress and can be seen in naphthalenetoxicity:

Generally more toxic by inhalation than byingestion:

Piperonyl butoxide is often added topyrethroids to do this to their metabolism

Most sensitive to organochlorine toxicity

An excitatory neurotoxin indogs and cats for which the mechanism of action has not been determined

Organophosphates may undergo storage __________ but carbamates do not

Onset of signs after toxic nicotine exposure

P-glycoprotein acts as this kind of pump to keepivermectin out of the CNS

Sometimes seen in amitraz toxicity due to thetoxin's effects on insulin

Inappropriate use of canine products on felines is a commoncause for this toxicity

Slowing Na+ efflux and K+ influx leading topartial depolarization of nerves is the main mechanism ofaction of what toxin group?

Enterohepatic recycling is significant inorganochlorine toxicity because of this feature of the toxin

Carbamate bond to AChE which is part of the reason 2-PAM is less effective:

Unlike OP toxicity in otheranimals, in ruminants you may see CNS __________

A more potent way to be exposed to rotenone:

A metabolite of DDT is o,p-DDD 
(mitotane)which can affect this gland

Functional adaptation and receptordownregulation can account for this seen in some chronic OP exposures:

Decontamination therapy for d-limonene exposureusually will involve this

Has a very long half-life(years) in soil:

Organophosphates that require lethal synthesisare generally toxic to very young animals

Minimum number of mothballs that could causetoxicity to a 6.5kg dog if ingested