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72 Cards in this Set
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- 3rd side (hint)
(5) Parkinsons drugs
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BALSA:
Bromocriptine, Amantadine, Levodopa, Selegiline, Antimuscarinics |
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Parkinson drug:
agonized dopamine receptors |
Bromocriptine
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Parkinson drug:
Increases Dopamine (2) |
Amantidine,
L-Dopa |
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Parkinson drug:
selectively inhibits MAO-B, thereby increasing availability of DA |
Selegiline
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Parkinson drug:
improves cholinergic activity (tremor and rigidity) |
Benztropine
(anti-muscarinic) |
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what coverts L-dopa to dopamine in the brain?
AE to periphreal L-dopa/carbidpoa |
Carboxylase
AE: Arrthymias |
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serotonin agonist causing vasoconstriction for Tx of migraine or cluster HA
what specific receptor? AE |
Sumatriptan
receptor: 5HT-1D AE: Coronary vasospasm |
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AE of Benzodiazepines
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Sedation
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(3) drugs that are first-line for Tonic-Clonic seizures
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PVC:
Phenytoin, Valproic Acid, Carbamazepine |
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(2) drugs that are first-line for Absent seizures
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Ethosuximide,
Valproic Acid |
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MOA of Valproic Acid
(3) AE Aside from Bipolar d/o, what other psych Dx can it be used for? |
MOA:
Na-channel (and Ca-channel) blocker AE: Hepatotoxicity, Neural tube defects in fetus, Tremor (also can be used for Schizophrenia) |
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What are the (4) Tx for Status Epilepticus
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Diazepam,
Lorazepam, Phenytoin, Phenobarbital |
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DOC for seizures in pregnant women and children
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Phenobarbital
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DOC for Trigeminal neuralgia, Tonic-Clonic seizures, schizophrenia and bipolar disorder
(2) AE what monthly test should be done to patient? |
Carbamazepine
AE: Hepatotoxicity; Aplastic Anemia monthly test: LFTs |
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(2) epilepsy drugs that can cause Stevens-Johnson syndrome
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Ethosuximide
Lamotrigine |
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MOA of Ethosuximide
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Blocks T-type Ca-channels
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epileptic drug that blocks Na channels and inhibits glutamate release from presynaptic neurons
AE (4) |
Phenytoin
AE: Gingival hyperplasia, Hirsutism, SLE-like syndrome, Nystagmus and ataxia |
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drug class that facilitates GABA action by increasing the duration of Cl- channel opening
contraindication? |
Barbiturates
[barbiDURATes inc DURATion] CI: Porphyria |
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Barbiturate that is used in ansthesia induction
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Thiopental
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drug class that facilitates GABA action by increasing the frequency of Cl- channel opening
use (4)* |
Benzodiazepines
use (Dumb ASS): Detoxification, Anxiety, Status epilepticus, Sleep issues (walking, terrors) |
Dumb ASS
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(3) short-acting Benzos
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short TOM thumb:
Triazolam, Oxazepam, Midazolam |
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DOC for Huntington's DZ
(3)* |
Practice Hunting Trees:
Phenothiazines, Haloperidol, Tetrabenazine |
Practice Hunting Trees
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DOC for Tourette's
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Haloperidol
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beta-blocker used to Tx tremor
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Propranolol
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DOC in Wilson's Dz
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Penicillamine
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(3)* Neuroleptic Antipsychotics that block the D2 receptors
main use? |
THC:
Thioridazine, Haloperidol, Chlorpromazine use: Schizophrenia |
THC
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AE of Neuroleptics (antipsychotics)
for each receptor blocked: 1. DA 2. Muscarinic 3. Alpha 4. Histamine |
DA: Hyperprolactinemia, gynecomastia
Muscarinic: dry mouth, constipation Alpha: Hypotension, Histamine: Sedation |
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Dx:
rigidity, myoglobinuria, autonomic instability, hyperpyrexia, recent Tx for schizophrenia Tx? (3 possible) |
Neuroleptic Malignant syndrome
Tx: 1. Bromocriptine 2. Amantidine 3. Dantrolene |
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Dx:
strange oral-facial movements, chorea, recent neuroleptic ingestion |
Tardive Dyskinesia
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(3) Atypical Antipsychotics
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OLanzapine, CLOZapine, RISPERidone
[its not ATYPICAL for OLd CLOZets to RISPER] |
its not ATYPICAL for OLd CLOZets to RISPER
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MOA of Atypical antipsychotics
which is used to Tx OCD? which causes Agranulocytosis as an AE? |
block Serotonin and Dopamine receptors
OLanzapine - OCD CLOZapine - Agranulocytosis |
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(4)* AE of Lithium
Use? |
Lithium
LMNOP: Lithium AE = Movement (tremor), Nephrogenic DI, hypOthyroidism, Pregnancy problems Use: Mood stabilizer for Bipolar disorder to block manic events |
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(4)* SSRIs
AE? (2) |
"the CITy PAROt FLU down SERTRAIL":
CITalopram, PAROxetine, FLUoxetine, SERTRALine AE: Sexual dysfunction and N/V |
the CITy PAROt FLU down SERTRAIL
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(3) TCAs
MOA Basic (not toxic) AE (2) |
CIA:
Clomipramine, Imipramine, Amitriptyline MOA: block reuptake of NE and Serotonin AE: Sedation, anticholinergic side effects |
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TCA used for bedwetting
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Imipramine
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TCA used for OCD
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Clomipramine
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Toxicity of TCA
(3) |
("Tri-C"):
Convulsions, Coma, Cardiotoxicity |
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(5)* Heterocyclic Antidepressants
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"you need BUtane in your VEINs to MURder for a MAP of alcaTRAZ"
BUproprion, VENlafaxine, MIRtazapine, MAProtiline, TRAZodone |
you need BUtane in your VEINs to MURder for a MAP of alcaTRAZ
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heterocyclic that also Tx smoking
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Bupropion
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heterocyclic that inhibits Serotonin, NE and DA reuptake
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Venlafaxine
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heterocyclic that is an alpha2-blocker
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Mirtazapine
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what (3) drugs can MAO-inhibitors not combine with?
why? |
Tyramine - HTN crisis
SSRI - Serotonin syndrome B-agonist - Serotonin syndrome |
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what does it mean if an anesthetic has a high solubility in blood?
(2) |
slower induction and slower recovery time
(Low blood solubility = rapid induction and recovery time) |
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what does it mean if an anesthetic has a high solubility in lipids?
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Increased Potency
High lipid solubility = 1/MAC |
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AE of Halothane
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Hepatotoxicity
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(5)* types of IV anesthetics
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B.B.King on OPIATES PROPOses FOOLishly:
Barbs, Benzos, Ketamine, Opiates, Propofol |
B.B.King on OPIATES PROPOses FOOLishly
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common Benzo used for endoscopy
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Midazolam
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how can you tell Amide local anesthetics versus esters?
MOA of locals |
AmIdes have 2 "I's" in the name
ex: LIdocaIne MOA: Na-channel blockers |
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which local anesthetic has cardiovascular toxicity?
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Bupivacaine
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used to Tx hyperthermia caused by inhalation anesthetics and neuroleptic malignant syndrome
MOA |
Dantrolene
MOA: prevents release of Ca from SR of skeletal muscles |
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what mixed agonist/antagonist of opioid receptors can place a person on Methadone back into withdrawal?
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Pentazocine
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what is the only opioid delivered parenterally?
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Fentanyl
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what is the only local anesthetic used topically?
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Benzocaine
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(2) MAO inhibitors
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Phenelzine,
Tranylcypromine |
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what NT does it block:
Neuroleptics |
Dompamine (D2)
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what NT does it block:
Atypical antipsychotics |
Serotonin
Dopamine |
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what (2) NT does it block:
TCAs |
Serotonin
NE |
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what NT does it block:
Heterocyclics |
Vary...
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which SSRI also inhibits NE?
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Fluoxetine
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which opiate receptor has the majority of the AE and Euphoria?
which has Dysphoria? |
U - Euphoria (and AE)
K - Dysphoria |
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in addition to Tx schizo, what abdominal Sx does Chlorpromazine Tx?
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Nausea and Vomiting
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what class of Antipsychotics have AE associated w/ blocking Dopamine, Muscarinic, alpha and Histamine receptors?
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Neuroleptics
Chlorpromazine ("-AZINES") and Haloperidol |
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Which Schizophrenic drug is also effective in minimizing the emotional bluntness and social withdrawal Sx?
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Olanzapine
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what "NSAID" does not inhibit prostaglandin synthesis?
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Acetaminophen
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general anesthetic that causes AE of Hyperthermia, HTN, HyperK, tachycardia, muscle rigidity and Metabolic Acidosis?
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Halothane
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which Benzo is good for alcohol withdrawal?
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Diazepam
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which anti-alcohol med causes nausea and vomiting w/ alcohol consumption?
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Disulfiram
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what Benzo is good versus Agoraphobia and Panic disorders?
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Alprazolam
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what anti-epileptic / anti-psychotic can induce seizures?
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Clozapine
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AE of Propofol
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Metabolic Acidosis
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list the progressive depression of the CNS
(5) |
Sedation -> Hypnosis -> Anesthesia ->
Coma -> death |
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what is the effect a local anesthetic has on nerve fibers?
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Pain -> Sensory -> Motor
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