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20 Cards in this Set
- Front
- Back
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How does the rate of elimination differ between zero and first order elmination? Which one behaves as though the enzyme responsible for the elimination are saturated?
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0 order elmination is constant regardless of C.
first order rate elminiation is prop to drug conc. first order behaves as such. |
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What are the side effects of the cGMP inhibitors (sildenafil, vardenafil, tadalafil)
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headache, flushing, dyspepsia, impaired blue green colored vision, risk of life threating hypotension if pt takinng nitrates
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Wha is the MCC of sudden cardiac death
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isquemic heart dz--due to lethal arrythmias
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What features might be seen in pts with narcolepsy? tx?
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disorder regulation of sleep wake cycles, hypnogogic and hypnopompic hallucinations, cataplexia
tx. amphetamines and modafanil |
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Which antiparasitic agent is best choice:
*tapeworm *bact vaginitis *pinworm *schistosomiasis *amoebic dysentery *lesihmaniasis *Chaga's *giardiasis |
tapeworm: prazaquintil
bact vaginitis: metronidazole pinworm: mebendazole/pirantil pamoate schistosomiasis: prazaquintal dysentery: metronidazole/ adaquinal leischmaniasis: sodium stabagluconate chaga's: nifurtimox giardiasis: metronidazole |
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What structures give rist to gas exchange barrier?
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type 1 eptith cells, tight jcts, BM
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What is the MCC of nephrotic syndrome in adults? children?
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adults: membranous glomerulonephritis
children. MCD |
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What lab value is elevated in a pt with a hydatidiform mole
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beta hcg
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What dz does JC virus cause? What pt pop is commonly affected?
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PML in AIDS pts
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what factor must be in place oin order for a pt to have the cap to make a decision?
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pt makes and communicates a choice, informed, decision remains stable, consistent with pts values and goal and decision is not assoc with hallucinations or dilusions
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What is the gen byproduct of phase I metabolism? phase II? What rxn take place in Phase I? phase II?
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byproduct phase I: reduction, oxidation and hydrolysis. Rxns yieds water sol metabolites that are still active. P450
byproduct II: acytelation, glucoronidation and sulfation. Rxns very polar inactive, renally excreted; conjugation |
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3 side effects of tricyclics
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convulsion, coma, cardiotox
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Collagen structure. Steps in collagen formation
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type 1 bone skin tendons,
type 2 cartilage type 3 skin blood vessel type 4 basement membrane steps: synthes, hydroxilaytio, glycosylation, exoctyosis |
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what is the general m.o.a. os steroid/thryoid hormones? which homrones are considred steroid hormones
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gene transcription and protein synth
steroid: progesteron, estrogen and testosterone |
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what is the role of LH and FSH in spermatogenesis?
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LH: leydig cells make testosterone
FSH: sertoli cells for sperm production |
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Which vasculitis is a/w elevations in P-ANCA? C-ANCA
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PANCA: polyarterits nodosa
CANCA: Wegener' |
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In what week will fetus reach landmarks
*implantation *organogenesis *heart beats *distinguish sex *gastrulation *formation of primitive streak and neural plate |
implantation: 1wk
organogenesis: 3-8wks heart beats: 4wks sex: 10 wks gastrulation: 3 wks primitive streak: 3 wks |
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m.o.a of methotrexate, 5-FU and cyclophosphamide
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MTX: S-phase specific antimetabolit, folic acid analog that inhibits dihydrofolate reductase --> down DTMP and down DNA protein synth
5FU: pyrimidine analog to 5FDUMP covantly complexes folic acid, inhibits thymidilate synthase downs dTMP cyclophosphamide: alkylating agent. DNA at guanine n7 require bioactivation by liver |
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75 y.o complains of pain and morning stiffenss in her MCP and PIP. What labs confirm
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RA
+ rheumatoid factor (anti IgG AB) assoc with HLA DR-4 |
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meds for EF of 30%
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cardiac glycosides, diuretics and ACE-I
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