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67 Cards in this Set

  • Front
  • Back

The nervous system derives from the

Ectoderm

The endoderm, mesoderm, and ectoderm make up the three layers of the

Gastrula

What’s the order? Oocyte, _______, Blastula, _________

Morula, Gastrula

Term for formation of the neural tube by the closing of the ectoderm

Neurulation

CNS and heart are the two parts of the body that develop ______

Fastest

Myelination starts in the ____ trimester

2nd

Human brain general growth:


CNS: ____ weeks


Fetus formed: 10 weeks


_____ ______: 13 weeks

3-5, primary sulci

the inner cell mass of the _________ is the future embryo

Blastocyst

the bilaminar germ disk forms in what week?

2nd

The epiblast and hypoblast are the layers of what?

Bilaminar germ disk, (epiblast becomes embryo)

The trilaminar germ disc forms in what week?

3rd

This is made up of the ectoderm, mesoderm, and endoderm

Trilaminar germ disk

What is the process by which the bilaminar germ disk becomes trilaminar?

Gastrulation

Which layer of the trilaminar germ disc has the notochord?

Mesoderm (middle)

The notochord is responsible for

Induction

________ is cell-cell interaction, where the secretion of one cell affects neighboring cells

Induction

The _____ _______ has to be completely closed, or else it leads to defects

Neural pore

What derives from the neural crest? (Frilly part outside of tube)

PNS sensory cells

What derives from the neural tube?

CNS Neurons

The organizer region does what in the neural tube?

Induction

How do you get two embryos in one system? (Two-headed fish)

Remove the organizer region from the dorsal part of one embryo, and put it into the ventral part of another embryo

T or F: Gradients of the amount of a gene, and variants of a gene, are key to how they function

TrueT or

T or F: The same gene can have different functions at different locations and timesGene

True

Genetic controls are ________ among different animal species

Conservative

What is BMP? If

Bone morphogenetic protein, (its inhibitors spread from the organizer region of an embryo)

If BMP signaling is inhibited, you get ______

neural tissue

If BMP signaling is NOT inhibited, you get ___________ tissue.

Epidermal

If the BHLH gene is activated, you get ______

neurons

If the Notch gene is activated, you get _________

Astrocytes (glia)

The three vesicle stage of brain development involves what three parts?

Proencephalon, mescencephalon, rhombencephalon

What does the proencephalon become?

Forebrain (telencephalon and diencephalon)

What does the rhombencephalon become?

Hindbrain (metencephalon, myelencephalon)

What is the correct order of the five secondary vesicles?

(T,D,Ms,Mt,My)

the ________ flexure becomes the mesencephalon (brain/spinal cord curve)

cephalic

The cervical flexure becomes the __________

rhombencephalon (spinal cord)

the ________ flexure becomes the myelencephalon and metencephalon

pontine

Anteroposterior (AP) patterning has to do with which gene?

Wnt

In the _______ part of the neural plate, there is low Wnt activity because Wnt inhibitors are high there

Anterior

In the posterior part of the neural plate there is _____ wnt activity

High

The AP (wnt) gradient works by turning on different TFs. _______ for anterior, and GBX2 for ______

OTx2 , posterior

What is the name of the longitudinal groove along the neural tube?

Sulcus limitans

Dorsoventral patterning in the spinal cord is controlled by the _________ and ________

roofplate and floorplate

The dorsal alar plate makes future _______ cells in the spinal cord

sensory

The ventral basal plate makes future _______ cells in the spinal cord

motor

The roofplate and floorplate function like the ________ in that they secrete chemicals in order to induce neuron development

notochord

Sonic hedgehog (shh) is the most important _______ molecule

Floorplate (motor)

What familiar molecule also exists in the roofplate, this time making cells in the dorsal alar plate to be sensory cells?There

BMP

There are many variants of ____ genes, which are responsible for segments, legs, and motor neurons

Hox

What is the name of the longitudinal groove along the neural tube?

Sulcus limitans

Dorsoventral patterning in the spinal cord is controlled by the _________ and ________

roofplate and floorplate

The dorsal alar plate makes future _______ cells in the spinal cord

sensory

The ventral basal plate makes future _______ cells in the spinal cord

motor

The roofplate and floorplate function like the ________ in that they secrete chemicals in order to induce neuron development

notochord

Sonic hedgehog (shh) is the most important _______ molecule

Floorplate (motor)

What familiar molecule also exists in the roofplate, this time making cells in the dorsal alar plate to be sensory cells?There

BMP

There are many variants of ____ genes, which are responsible for segments, legs, and motor neurons

Hox

In AP patterning, _______ is the main inducer and determines what TFs are expressed.


Anterior has a high gradient of Pax 6, and posterior has EMX 2.

FGF 8

What is the name of the longitudinal groove along the neural tube?

Sulcus limitans

Dorsoventral patterning in the spinal cord is controlled by the _________ and ________

roofplate and floorplate

The dorsal alar plate makes future _______ cells in the spinal cord

sensory

The ventral basal plate makes future _______ cells in the spinal cord

motor

The roofplate and floorplate function like the ________ in that they secrete chemicals in order to induce neuron development

notochord

Sonic hedgehog (shh) is the most important _______ molecule

Floorplate (motor)

What familiar molecule also exists in the roofplate, this time making cells in the dorsal alar plate to be sensory cells?There

BMP

There are many variants of ____ genes, which are responsible for segments, legs, and motor neurons

Hox

In AP patterning, _______ is the main inducer and determines what TFs are expressed.


Anterior has a high gradient of Pax 6, and posterior has EMX 2.

FGF 8

The anterior part of the forebrain is for _____ and somatosensory, and posterior part is for the auditory and _______ cortices

motor, visual