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62 Cards in this Set
- Front
- Back
Secondary Motor Symptoms Most common symptom (Sullivan) |
fatigue |
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Secondary Motor Symptoms - Characterized by a progressive increase in speed with a shortening of stride |
festinating gait |
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Secondary Motor Symptoms festinating gait types: |
Anteropulsive(forward)= Retropulsive(backward) |
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Same with festinating but with decreased velocity |
shuffling gait |
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Freezing of gait |
shuffling gait |
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Sudden stops in movement |
freezing of gait/ freezing phenomenon |
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Secondary to "off-stat" |
freezing of gait/ freezing phenomenon |
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Non-motorsymptoms • Sensory symptoms |
- Paresthesias - Pain - Olfactory dysfunction (anosmia) |
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common with/ secondary to off state (levadopa- stops or not working) |
freezing of gait/ freezing phenomenon |
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Non-motor symptoms: pins & needles |
Paresthesias |
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Non-motor symptoms: secondary to rigidity |
Pain |
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Non-motor symptoms: CN involved in PD: |
CN 1,3,7,9 olfactory oculomotor facial glossopharyngeal |
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Non-motor symptoms: impaired swallowing |
Dysphagia |
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Non-motor symptoms: May result to sialorrhea or excessive drooling |
Dysphagia |
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Non-motor symptoms: • Speech disorder |
Hypokinetic dysarthria |
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Non-motor symptoms: Characterized by decrease voice volume, monotone speech, distorted articulation and controlled speech rate |
Hypokinetic dysarthria |
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Non-motor symptoms: Cognitive dysfunction |
- Mild (impaired memory) - Severe (psychosis) |
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Non-motor symptoms of PD |
• Sensory symptoms • Dysphagia • Speech disorder • Cognitive dysfunction • Depression and anxiety • Autonomic dysfunction • Sleep disorder |
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Non-motor symptoms: Sleep.disorder |
Excessive day time somnolence (sleepiness) Insomnia REM (rapid eye mvmt) sleep behavior disorder |
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Non-motor symptoms: autoimmune disfunctions |
(+) lewy bodies in the ANS seborrhea GI d/o urinary incontinence erectile dysfunction OH |
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cytoplasmic incision bodies d/t neuronal degeneration |
(+) lewy bodies in the ANS |
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proteins |
(+) lewy bodies in the ANS |
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increase oil production/ secretion |
seborrhea |
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MC GI d/o in PD pt? |
constipation |
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Associated with cell loss in the caudate nucleus and putamen |
Huntington disease |
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Huntington disease Cardinal features: |
Dementia Depression Chorea |
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hallmark of Huntington disease |
chorea |
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Onset:3rd or 4th decade of life (30-40) |
Huntington disease |
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MC cause of death: pneumonia and cardiovascular disease |
Huntington disease |
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Mutation of huntingtin |
Huntington disease |
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Progressive disorder characterized by gait ataxia with diminished nuscle stretch reflexes joint, position sense, and vibratory sense |
Friedrich Ataxia |
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MOI: Autosomal dominant (AD) |
Huntington disease |
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AR autosomal recessive |
Friedrich Ataxia |
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Onset: Teens |
Friedrich Ataxia |
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Mutation in FRATAXIN |
Friedrich Ataxia |
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Hereditary Spastic Paraparesis Aka: |
Familial Spastic Paraplegia Strumpell-Lorrain Syndrome |
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Progressive bilateral lower limb spasticity and weakness |
Hereditary Spastic Paraparesis |
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MOl: AD, AR, X-linked |
Hereditary Spastic Paraparesis |
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32 HSP loci and 11 HSP |
Hereditary Spastic Paraparesis |
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Abnormal contraction of the eyelid muscles |
Eyes (blepharospasm) |
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Sustained contraction of agonist and antagonist muscle |
Dystonia |
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Dystonia examples: |
Ex: Cervical dystonia (torticollis) Eyes (blepharospasm) |
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MC focal dystonia |
Cervical dystonia (torticollis) |
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AD (idiopathic) |
Tourette syndrome |
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a constellation of symptoms including tic disorders and comorbid neurobehavioral problems |
Tourette syndrome |
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Involuntary, sudden, rapid, repetitive, non rhythmic,stereotyped movements or vocalizations |
Tics |
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(+) Tics |
Tourette syndrome |
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most serious complication of PD |
bronchopneumonia/ Pneumonia |
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MC cause of death in PD |
bronchopneumonia/ Pneumonia |
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purposeless uniformity repetitive voluntary contraction/movement |
stereotypsy |
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common: head nodding head bang |
stereotypsy |
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subject restlessness & compulsion to move about |
akathisia |
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common in LE (+) toe tapping (+) leg shaking |
akathisia |
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sudden brief, irregular contraction of a group of muscle that may occur at rest or with voluntary movement |
myoclonus |
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example: hiccups asterexis |
myoclonus |
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asynchronous ms. twitching |
asterexis |
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rapid, jerky, irregular mvmt |
chorea |
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slow & writhing mvmt |
athetosis |
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slow & fluid motion |
athetosis |
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worm-like mvmnt |
athetosis |
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MC in proximal limb |
ballismus |
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Autosomal dominant disorders |
huntington's disease hereditary spastic paraparesis Tourette syndrome |