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17 Cards in this Set
- Front
- Back
- 3rd side (hint)
Quinidine
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Class IA - Na+ channel blocker
Slow phase 0, prolong action potential, increase ventricular effective refractory period Intermediate speed of association with activated/inactivated Na+ channels |
Atrial, AV-junctional, and ventricular tachyarrhythmias; Maintenance of sinus rhythm after direct current cardioversion of Afib or flutter
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Disopyramide
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Class IA - Na+ channel blocker
Slow phase 0, prolong action potential, increase ventricular effective refractory period Intermediate speed of association with activated/inactivated Na+ channels |
Atrial, AV-junctional, and ventricular tachyarrhythmias; Maintenance of sinus rhythm after direct current cardioversion of Afib or flutter
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Procainamide
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Class IA - Na+ channel blocker
Slow phase 0, prolong action potential, increase ventricular effective refractory period Intermediate speed of association with activated/inactivated Na+ channels |
Atrial, AV-junctional, and ventricular tachyarrhythmias; Maintenance of sinus rhythm after direct current cardioversion of Afib or flutter
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Lidocaine
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Class IB - Na+ channel blocker
Shorten phase 3 repolarization Rapid interaction with Na+ channels |
Ventricular arrhythmias resulting from myocardial ischemia
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Tocainide
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Class IB - Na+ channel blocker
Mild decrease in slope of Phase 0. Shorten phase 3 repolarization Rapid interaction with Na+ channels |
Treatment of ventricular tachyarrhythmia
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Mexiletine
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Class IB - Na+ channel blocker
Shorten phase 3 repolarization Rapid interaction with Na+ channels |
Chronic treatment of ventricular arrhythmias associated with MI
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Flecainide
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Class IC - Na+ channel blocker
Markedly slows phase 0 depolarization, little effect on duration of membrane action potential or refractory periods Slow interaction with Na+ channels |
Refractory ventricular arrhythmias; paroxysmal atrial fib or flutter, PSVT
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Propafenone
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Class IC - Na+ channel blocker
Markedly slows phase 0 depolarization, little effect on duration of membrane action potential or refractory periods Slow interaction with Na+ channels |
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Moricizine
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Class IC - Na+ channel blocker
Markedly slows phase 0 depolarization, little effect on duration of membrane action potential or refractory periods Slow interaction with Na+ channels |
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Amiodarone
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Class III - K+ channel blocker
Prolongation of the action potential duration and refractory period Exhibits activity from all 4 classes of antiarrhythmic drugs |
Severe refractory ventricular and supraventricular tachyarrhythmias
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Ibutilide
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Class III - K+ channel blocker
Prolongation of the action potential duration and refractory period |
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Dofetilide
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Class III - K+ channel blocker
Prolongation of the action potential duration and refractory period |
1st line in pts with persistent atrial fib and heart failure or in CAD with impaired LV function
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Sotalol
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Class III - K+ channel (delayed rectifier) blocker but also has β-blocker activity
Prolongation of the action potential duration and refractory period |
Prevent sudden death following acute MI
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Verapamil
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Class IV - Ca2+ blockers
Use-dependent Decrease rate of Phase 4 spontaneous depolarization Slow conduction in tissue dependent on calcium current (e.g. AV node) Affects heart > vascular smooth muscle |
Atrial arrhythmias; reentrant supraventricular tachycardia; reducing ventricular rate in Afib and flutter; hypertension; angina
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Diltiazem
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Class IV - Ca2+ blockers
Use-dependent Decrease rate of Phase 4 spontaneous depolarization Slow conduction in tissue dependent on calcium current (e.g. AV node) Intermediate activity between heart and vascular smooth muscle |
Atrial arrhythmias; reentrant supraventricular tachycardia; reducing ventricular rate in Afib and flutter; hypertension; angina
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Digoxin
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Shortens refractory period in atrial and ventricular myocardium while prolonging refractory period and diminishing conduction velocity in AV node
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Adenosine
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At high doses, decreases conduction velocity, prolongs refractory period & decreases automaticity of AV node
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