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13 Cards in this Set
- Front
- Back
Non-polar groups (7)
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Gly-G ---- Ala-A ----- Pro-P ------ Val-V -----Leu-L------- Ile-I----- Met-M
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Aromatic R (3) -- tYYYr
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Phe-F------ Tyr-Y-------Trp-W
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Polar uncharged (5) --- asparagiNNNe
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Ser-S------Thr-T-------Cys-C------Asn-N------Gln-Q (most abund)
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Negative charged -1 (2) --- aspartATE ---- MSG (5C)
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Asp-D-----Glu-E (neurotransmitter)
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Positive charged +1 (3) -- aRRRg
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Lys-K------Arg-R------His-H
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OH ------------SH --------H2N-C=O----------COO-----------NH3-NH4 --- noncharged----- Arom
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ST---CM----NQ-----ED-------KRH---- GAPVLIM------FYW
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His positive when
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when pH<6.0 in pronated form --> low pH lots of H add H in
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Sickle cell --- less water soluble --- brittle ---- treatment
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Glu --> Val on #6 (neg - vs nonpolar) ---> noncharged less polar water is polar ----- crystalize ----- give more O2
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pH=pKa + log (B/A) -- protonation state (acid state) --> base/Acid
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--> pH determine the drug in its acid form or basic form
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What is the pH at which we have 10 times more of the acid form than the basic form for the drug “aspirin”? pKa=3.5
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pH=pKa + log (B/A) ---- pH = 3.5 + log (1/10) --> pH = 3.5 - 1 = 2.5 --- more acid in stomach ---- need enteric coating
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pI and buffer capacity
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at pI: drug has no charges ---- buffer in 1 pH unit of its pKa
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His pI --> use the point of 0 charged
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pI=(6.0+9.17)/2=7.59 (when it has both + and -)
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Protein cross-link Cys (curly hair)
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A disulfide bridge
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