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38 Cards in this Set
- Front
- Back
4 key features of lymphocytes
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Circulate
Individual AG receptors in plasma membrane Clonal proliferation Confers memory to adaptive immune system |
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Two primary divisions of T-lymphocytes
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Tαβ
Tγδ |
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Which class of T-lymphocytes is divided into CD4 and CD8?
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Tαβ
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Primary function of B lymphocytes
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Secrete ABs
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AG receptors for B lymphocytes
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Membrane bound immunoglobulin
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Identifying surface molecules for B lymphocytes
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IgA, IgB
(AKA CD79a and CD79b) |
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Location of B lymphocytes in secondary lymphoid tissues
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Follicles/nodules
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Location of T lymphocytes in secondary lymphoid tissues
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Diffuse tissue
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AG receptors for T lymphocytes
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TCR
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What is the identifying surface molecule located on all T-lymphocytes?
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CD3
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What is the identifying surface molecule located on all helper T-lymphocytes?
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CD-4
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What is the identifying surface molecule located on all cytotoxic T-lymphocytes?
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CD-8
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Function of Th1 T-lymphocytes
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Activate macrophages
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Function of Th2 T-lymphocytes
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Activate eosinophils
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Function of Th17 T-lymphocytes
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Activate neutrophil
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Function of Tfh T-lymphocytes
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Activate B lymphocytes
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Which MHC class is associated with B lymphocytes?
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MHC Class II
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Which MHC class is associated with CD4?
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II
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Which MHC class is associated with CD8?
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I
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Primary Lymphoid Tissues (4)
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- Thymus
- Bone Marrow - Ileal Peyer's patches - Cloacal bursa |
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Where do all lymphocytes originate from?
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Bone marrow
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Where do T lymphocytes mature?
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Thymus in all species
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Where do B lymphocytes mature in the bird?
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Cloacal bursa
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Where do B lymphocytes mature in primates and rodents?
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Bone marrow
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Where do B lymphocytes mature in ruminants, pigs, and dogs?
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Ileal Peyer's patches
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Secondary Lymphoid tissues (3)
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- Spleen
- MALT - Lymph nodes |
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Function of the spleen
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Filters blood-borne AGs
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Function of MALT
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Filters AGs entering at mucosal surfaces
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Function of lymph nodes
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Filters AGs in lymphatics
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Where are B lymphocytes generally found?
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Nodular/follicular structures
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Where are T lymphocytes generally found?
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Diffuse lymphatic tissue
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What type of lymphocytes circulate between blood and secondary lymphoid tissues?
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Naive
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Where do mature memory lymphocytes generally go?
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Back to the tissue they were activated in
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MALT stands for?
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Mucousal Activated Lymphatic Tissue
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Where does the problem with maturation of lymphocytes come from?
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Rearrangement of receptor genes is somewhat random, allowing for self recognition by accident
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Name for the process of selecting against self-recognition T-lymphs
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'Negative selection'
Anything that tests strongly against self dies. |
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Three possibilities of positive selection in T lymphocytes
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CD 4
CD 8 Death |
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Four possibilities of negative selection in T lymphocytes
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Th
Tc Treg Death |