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41 Cards in this Set
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- 3rd side (hint)
Nuclear abnormality: |
Hypersegmented neutrophil |
More than 5 lobes Problem: DNA synthesis Vitamin b12 and folate deficiency Pernicious anemia Megaloblastic andmia |
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Nuclear abnormality: |
Pegler-Huet Anomaly |
Hyposegmented neutrophil Nucleus: dumbbell, pair of glasses, spectacle, peanut Benign anomaly Acquired-autosomal dominant disorder |
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Nuclear abnormality: |
Barr Body/ Sex-Chromatin bodies |
Small round projection of nuclear chromatin 2nd X chromosome of females (<20% of females) 2-3% female |
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Nuclear abnormality: |
Giant Neutrophil |
Larger Occasionally seen in normal peripheral circulation Often observed in hypersegmented neutrophils |
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Cytoplasmic abnormality: |
Alder-reilly inclusions |
Granules: Purple-red, precipitated mucopolysaccharides Found in: 1. granulocytes 2.monocytes/lymphocytes Larger than toxic granulation Test: CTAB --- (+) white turbidity -Hurler's and Hunter's syndrome |
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Cytoplasmic abnormality: |
Auer rods |
Reddish-purple, rod-like bodies Represents: primary granules Test: peroxidase Normal: low number Abnormal: high number -Acute myelogenous leukemia |
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Cytoplasmic abnormality: |
Chediak-Higashi granules |
Impaired chemotaxis Granules: large reddish-purple Lysosomal granules test: peroxidase, sudan black B -Hereditary disease (autosomal recessive) |
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Cytoplasmic abnormality: |
Dohle bodies/Amato bodies |
Single/multiple at periphery of cytoplasm 1. Neutrophil 2. Monocytes/Lymphocytes Wright stain: light blue Represents: aggregation of RER -Burns, viral infxn, certain drug therapy |
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Cytoplasmic abnormality: |
Toxic granulation |
Granules: dark blue-black RNA precipitation Test: peroxidase Seen in: band & segmented neutrophils -burns, drugs therapy/poisoning |
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Cytoplasmic abnormality: |
Jordan's anomaly/ Toxic vacuolation |
Vacuolation in phagocytes (granulocytes, monocytes) Aging and active phagocytosis Increased lysosomal activity - fatty degeneration & glycogen -septicemia, severe infxn |
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Cytoplasmic abnormality: |
May-hegglin anomaly |
Platelets and granulocyte anomaly With dohle like inclusion granulocytes -giant platelets, thrombocytopenia |
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Phagocytes abnormality: |
LE cells |
NEUTROPHIL w/ large purple homogenous round inclusion w/ nucleus wrapped around Smooth and evenly stained -Lupus eythematosus (autoimmune) |
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Phagocytes abnormality: |
Tart cells |
MONOCYTES with ingested lymphocyte Rough and unevenly stained |
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Lymphocyte abnormality: |
Downey cells/Atypical lymphocytes (Reactive/Variant/Transformed lymphocytes, Leukocytoid) |
Type 1: Turk's irritation cells/plasmacytoid lymphocytes with large block chromatin Type 2: Infectious Mononucleosis (ballerina skirt appearance) Type 3: (swiss cheese/moth-eaten appearance) |
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Lymphocyte abnormality: |
Basket cell/smudge cell |
Squashed degenerative nuclei -chronic lymphocytic leukemia |
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Lymphocyte abnormality: |
Hairy cells |
B- lymphocyte with hair-like cytoplasmic projections Test: TRAP -Hairy cell leukemia |
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Lymphocyte abnormality: |
Sezary cells |
Have T cell characteristics Grooved nucleus Brain-like convolutions (cerebri form) -sezary syndrome, mycosis fungiodes, cutaneous T cell lymphoma |
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Plasma abnormality: |
Flame cell |
Red to pink cytoplasm Increased IgA -multiple myeloma |
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Plasma abnormality: |
Russell antibodies |
Individual globules of Igs -multiple myeloma, reactive state |
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Plasma abnormality: |
Morula cell/Molt cell/Grape cell/Berry cell |
Vacuoles and large protein globules Grape-like -multiple myeloma, reactive state |
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Plasma abnormality: |
Dutcher's bodies |
Intranuclear inclusions |
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1. Neutrophil 2. Monocytes 3. Lymphocyte 4. Erythrocyte 5. Platelet 6. Eosinophil 7. Neutrophil 8. Basophil |
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Hypersegmented neutrophil |
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Pegler-Huet anomaly (dumbbell) |
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Pseudo Pegler-Huet (round) |
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Alder-reilly inclusions |
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Chediak-Higashi granules |
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Dohle bodies |
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Toxic granulation |
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May-Hegglin anomaly |
Abnormally Large platelet |
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Basket cell/Smudge cell |
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Downey cell/atypical lymphocyte |
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Hairy cell |
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Sezary cell |
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Flame cell |
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Russel bodies |
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Grape/Berry/Morula/Molt cell |
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Dutcher's bodies |
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