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18 Cards in this Set
- Front
- Back
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"Pill Cervix"
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microglandular hyperplasia (Progesterone effect)
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What 2 bugs may cause acute cervicitiis?
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gonococcus or chlamydia
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High risk types of HPV that is found in precacnerous cervical mucosa
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16,18,31,33
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HPV virus in condyloma accuminatum and warts reamain ____
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episomal
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___ oncoprotein product of HPV binds with and degrades p53; _____ oncoprotein binds hypophosphorylated pRb,
frees E2F transcription factor to drive cell cycle |
E6; E7
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koilocytes
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HPV infected cells; nuclear size, N/C, irregular nuclear contours, hyperchromasia and perinuclear clearing
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CIN III also called what?
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Carcinoma in situ
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Where do cervical lesions begin?
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Transformatino zone (squamo-columnar jxn)
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iodine (Schiller’s) test—stains glycogen in normal cells for dx
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Cervical cancer (Done before we had a good colposcopy:use acetic acid and bx technique)
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Stage 0 of Invasive cervical cancer
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CIN III
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Stage 1 of Invasive Cervical Carcioma
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limited to cervix
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Stage 2 of Invasive Cervical Carcioma
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Beyond cervix upper 1/3 vagina, does not reach pelvic wall
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Stage 3 of Invasive Cervical Carcioma
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lower 1/2 vagina & reaches pelvic wall
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Stage 4 of Invasive Cervical Carcioma
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beyond pelvis or invaded bladder or colon; distant metastases
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Where is cervical cancer likely to met?
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uterers, colon and bladder
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Nabothian cysts
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squamous metaplasia of endocervical mucosa (Chronic cervicitis)
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MC Types of HPV found in high grade cervical lesions
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16 and 18 (31,33,35 too, but not as often)
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Types of HPV MC in condylomas
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6 and 11
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