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46 Cards in this Set
- Front
- Back
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Which DNA viruses are double stranded?
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All DNA viruses except for Parvoviridae - Mnemonic: All are dsDNA like ours, except "Part-of-a-virus" which is ss.
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Which DNA viruses are single stranded?
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Parvoviridae
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Which DNA viruses have linear genomes?
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All except papova virus and hepadna which are circular
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Which DNA viruses have circular genomes?
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papova virus and hepadna which are circular
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Which DNA viruses have infectious naked nucleic acids?
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Most dsDNA Herpes, Adeno, Papov (except poxvirus and HBV)
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Which DNA viruses have non-infectious naked nucleic acids?
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poxvirus and HBV
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Which enveloped viruses acquire their envelopes from the plasma membrane?
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All except herpesviruses (nuclear membrane)
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Which enveloped viruses acquire their envelopes from the nuclear membrane?
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Only herpesviruses
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Where do DNA viruses replicate?
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In the nucleus (except pox)
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DNA virus families
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Mnemonic: DNA viruses are HHAPPPy - 1. Hepadna 2. Herpesviruses 3. Adenovirus 4. Parvovirus 5. Papovavirus 6. Poxvirus
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Which DNA viruses are icosahedral?
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All except pox (complex)
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Which DNA viruses replicate in the nucleus?
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All except pox (carries own DNA-dependent RNA polymerases)
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Which DNA viruses are naked (no envelope)?
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Mnem: Get naked for your PAP - 1. Parvo 2. Adeno 3. Papova
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Which DNA viruses are enveloped?
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HPH: 1. Hepadna 2. Pox 3. Herpes
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Medical importance of HSV-1
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1. Oral (and some genital) lesions (Gingivostomatitis) 2. Keratoconjunctivitis 3. Temporal lobe encephalitis
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Medical importance of HSV-2
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Genital (and some oral) lesions
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Medical importance of VZV
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1. Chickenpox 2. Shingles 3. Encephalitis 4. Pneumonia
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Medical importance of EBV
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1. Mononucleosis 2. Burkitt's lymphoma
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Medical importance of CMV
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1. Infection in immunosuppressed (especially transplant) 2. Congenital defects 3. Mononucleosis (negativie Monospot) 4. Pneumonia
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Medical importance of HHV-6
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Roseola (exanthem subitum): 1. High fever lasting 3 to 5 days which resolves and is followed by rash 2. Rash: mostly on trunk, lasting a day or two
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Medical importance of HHV-8
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Kaposi's sarcoma-associated herpesvirus
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List of important Herpesviruses
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1. HSV 1
2. HSV 2 3. VZV 4. EBV 5. CMV 6. HHV 6 7. HHV 8 |
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Medical importance of Adenovirus
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1. Febrile pharyngitis (sore throat) 2. Pneumonia 3. Conjunctivitis (pink eye)
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Medical importance of Parvovirus
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B19 virus causes: 1. Aplastic crises in sickle cell disease 2. "slapped cheeks" rash---erythema infectiosum (fifth disease) 3. Hydrops fetalis
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List of Papova viruses
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1. Papilloma 2. Polyoma (human BK and JC) 3. Simian Vacuolating virus (does not affect humans)
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Medical importance of Papilloma virus
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causes warts and cervical cancer, including CIN (cervical intraepithelial neoplasia)
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Medical importance of JC virus
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Progressive multifocal leukoencephalopathy in HIV
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List of Pox viruses
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1. Smallpox 2. Vaccinia (cowpox "milkmaid's blisters") 3. Molluscum contagiosum
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How is HSV-1 transmitted?
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Respiratory secretions and saliva
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How is HSV-2 transmitted?
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Sexual contact and perinatally
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How is VZV transmitted?
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Respiratory secretions
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How is EBV transmitted?
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Respiratory secretions, saliva
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How is CMV transmitted?
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1. Congenital 2. Transfusion 3. Sexual contact 4. Saliva 5. Urine 6. Transplant
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How is HHV-8 transmitted?
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Sexual contact
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Treatment for CMV
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Ganciclovir or Foscarnet
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What kind of cell does Epstein Barr virus infect?
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B cells
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How does mononucleosis present?
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1. Fever 2. Hepatosplenomegaly 3. Pharyngitis 4. Lymphadenopathy (especially posterior auricular nodes)
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Peak incidence of mononucleosis
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15-20 years old (peak kissing years)
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Laboratory diagnosis of mononucleosis
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1. Monospot test: Heterophil antibodies detected by agglutination of sheep RBCs. In EBV, positive. In CMV, negative. 2. Abnormal circulating CD8 cells.
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Tzanck test
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Smear of opened skin vesicle to detect multinucleated giant cells. Used to assay for HSV-1, HSV-2, VZV - Mnem: Tzanck heavens I do not have herpes. (helps if you do it in an eastern european accent)
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DNA, DS, circular, enveloped virus?
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Hepadnavirus
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DNA, DS, linear, enveloped virus?
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Herpesviruses and Pox (largest DNA virus)
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DNA, DS, linear, nonenveloped virus?
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Adenovirus
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DNA, SS, -linear, nonenveloped virus?
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Parvovirus
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DNA, DS, circular, nonenveloped virus?
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Papovavirus
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DNA, DS, -linear, enveloped virus?
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Poxvirus
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