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8 Cards in this Set
- Front
- Back
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Define drug What are the two types of drug? |
Achemical entity which alters body function which we use for the prevention ortreatment of disease small molecules and biologics |
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What are the four requirements for a working drug? |
- Therapeutictarget involved in the disease process - Drugmust get to site of action - Drugsmust bind to target / receptor - Thenexhibits required response |
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List the 4 types of drug receptor and the general type of effect which a targeted drug will have |
- enzyme linked: multiple actions - ion channel linked: quick - g protein linked: amplifier - nuclear (gene target): long-lasting |
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Define affinity |
measureof propensity of a drug to bind receptor; the attractiveness of drug andreceptor |
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Define efficacy |
Efficacy(or Intrinsic Activity) – ability of a bound drug to change the receptorin a way that produces an effect; some drugs possess affinity but NOT efficacy |
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Describe the differnce between agonist, antagonists, partial agonists and competitive agonists |
Agonisthas affinity and intrinsic activity Antagonisthas affinity but no intrinsic activity (bind to receptor but won't change it) Partialagonist has affinity but less intrinsic activity Competitiveantagonists can be overcome |
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Describe what is meant by ED50, TD50 and LD50 |
ED50- Median Effective Dose 50; the dose at which 50 percent of the population orsample manifests a given effect; used with quantal dose response curves TD50- Median Toxic Dose 50 - dose at which 50 percent of the population manifests agiven toxic effect LD50- Median Lethal Dose 50 - dose which kills 50 percent of the subjects |
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How do you calculate therapeitic index? |
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